Gene name: CBLN2

Uniprot entry:

Q8IUK8

Protein names:

Cerebellin-2

Protein sequence:

1_MQAPG 6_ RGPLG 11_ LRLMM 16_ PGRRG 21_ ALREP 26_ GGCGS 31_ CLGVA 36_ LALLL 41_ LLLPA 46_ CCPVR 51_ AQNDT 56_ EPIVL 61_ EGKCL 66_ VVCDS 71_ SPSAD 76_ GAVTS 81_ SLGIS 86_ VRSGS 91_ AKVAF 96_ SATRS 101_ TNHEP 106_ SEMSN 111_ RTMTI 116_ YFDQV 121_ LVNIG 126_ NHFDL 131_ ASSIF 136_ VAPRK 141_ GIYSF 146_ SFHVV 151_ KVYNR 156_ QTIQV 161_ SLMQN 166_ GYPVI 171_ SAFAG 176_ DQDVT 181_ REAAS 186_ NGVLL 191_ LMERE 196_ DKVHL 201_ KLERG 206_ NLMGG 211_ WKYST 216_FSGFL

Protein annotations

Protein functions:

1: Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long-term maintenance but not establishment of excitatory synapses. Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response