C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301)
1_MTRTY 6_ ENFQY 11_ LENKV 16_ KVQGF 21_ KNGPL 26_ PLQSL 31_ LQRLC 36_ SGPCH 41_ LLLSL 46_ GLGLL 51_ LLVII 56_ CVVGF 61_ QNSKF 66_ QRDLV 71_ TLRTD 76_ FSNFT 81_ SNTVA 86_ EIQAL 91_ TSQGS 96_ SLEET 101_ IASLK 106_ AEVEG 111_ FKQER 116_ QAGVS 121_ ELQEH 126_ TTQKA 131_ HLGHC 136_ PHCPS 141_ VCVPV 146_ HSEML 151_ LRVQQ 156_ LVQDL 161_ KKLTC 166_ QVATL 171_ NNNAS 176_ TEGTC 181_ CPVNW 186_ VEHQD 191_ SCYWF 196_ SHSGM 201_ SWAEA 206_ EKYCQ 211_ LKNAH 216_ LVVIN 221_ SREEQ 226_ NFVQK 231_ YLGSA 236_ YTWMG 241_ LSDPE 246_ GAWKW 251_ VDGTD 256_ YATGF 261_ QNWKP 266_ GQPDD 271_ WQGHG 276_ LGGGE 281_ DCAHF 286_ HPDGR 291_ WNDDV 296_ CQRPY 301_ HWVCE 306_ AGLGQ 311_TSQES
1: C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs) (PubMed:15802303, PubMed:16998493, PubMed:17616966, PubMed:22213806, PubMed:33724805, PubMed:8598452). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides (PubMed:15802303, PubMed:23507963). Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions (PubMed:15802303, PubMed:16998493, PubMed:22213806). Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively (PubMed:15802303, PubMed:17616966, PubMed:17804752)