DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F)
1_MKPHF 6_ RNTVE 11_ RMYRD 16_ TFSYN 21_ FYNRP 26_ ILSRR 31_ NTVWL 36_ CYEVK 41_ TKGPS 46_ RPRLD 51_ AKIFR 56_ GQVYS 61_ QPEHH 66_ AEMCF 71_ LSWFC 76_ GNQLP 81_ AYKCF 86_ QITWF 91_ VSWTP 96_ CPDCV 101_ AKLAE 106_ FLAEH 111_ PNVTL 116_ TISAA 121_ RLYYY 126_ WERDY 131_ RRALC 136_ RLSQA 141_ GARVK 146_ IMDDE 151_ EFAYC 156_ WENFV 161_ YSEGQ 166_ PFMPW 171_ YKFDD 176_ NYAFL 181_ HRTLK 186_ EILRN 191_ PMEAM 196_ YPHIF 201_ YFHFK 206_ NLRKA 211_ YGRNE 216_ SWLCF 221_ TMEVV 226_ KHHSP 231_ VSWKR 236_ GVFRN 241_ QVDPE 246_ THCHA 251_ ERCFL 256_ SWFCD 261_ DILSP 266_ NTNYE 271_ VTWYT 276_ SWSPC 281_ PECAG 286_ EVAEF 291_ LARHS 296_ NVNLT 301_ IFTAR 306_ LYYFW 311_ DTDYQ 316_ EGLRS 321_ LSQEG 326_ ASVEI 331_ MGYKD 336_ FKYCW 341_ ENFVY 346_ NDDEP 351_ FKPWK 356_ GLKYN 361_ FLFLD 366_SKLQE
1: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:15141007, PubMed:20062055, PubMed:22915799, PubMed:34774569). Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 (PubMed:15141007, PubMed:15152192, PubMed:20219927, PubMed:21835787, PubMed:22807680, PubMed:23001005, PubMed:23097438, PubMed:23152537, PubMed:34774569). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:15141007). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells (PubMed:15141007). Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (PubMed:15141007). Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons (PubMed:16378963, PubMed:16527742, PubMed:19458006, PubMed:20062055, PubMed:20335265). May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (PubMed:21496894)