GRAM domain-containing protein 2A
1_MTALS 6_ RSEAT 11_ EEGGN 16_ QQMHR 21_ KTASL 26_ NSPVS 31_ CKEKP 36_ DRVEE 41_ PPDYS 46_ LHWPE 51_ GLKGE 56_ EIKKC 61_ GREGI 66_ TLNKY 71_ NQQYH 76_ KLFKD 81_ VPLEE 86_ VVLKV 91_ CSCAL 96_ QRDFL 101_ LQGRL 106_ YISPN 111_ WLCFH 116_ ASLFG 121_ KDIKV 126_ VIPVV 131_ SVQMI 136_ KKHKM 141_ ARLLP 146_ NGLAI 151_ TTNTS 156_ QKYIF 161_ VSLLS 166_ RDSVY 171_ DLLRR 176_ VCTHL 181_ QPSSK 186_ KSLSV 191_ REFSG 196_ EPESL 201_ EVLIP 206_ EMKWR 211_ KVCPS 216_ SRSLS 221_ LPDNI 226_ PCIPP 231_ SSVDS 236_ TDSFF 241_ PSRKP 246_ PMSEK 251_ SRAQV 256_ ASENG 261_ GRWAW 266_ PMPGW 271_ GPACP 276_ KKMPN 281_ CSPTA 286_ KNAVY 291_ EEDEL 296_ EEEPR 301_ STGEL 306_ RLWDY 311_ RLLKV 316_ FFVLI 321_ CFLVM 326_ SSSYL 331_ AFRIS 336_ RLEQQ 341_ LCSLS 346_WDDPV
1: Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE)