Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1)
1_MKALG 6_ AVLLA 11_ LLLFG 16_ RPGRG 21_ QTQQE 26_ EEEED 31_ EDHGP 36_ DDYDE 41_ EDEDE 46_ VEEEE 51_ TNRLP 56_ GGRSR 61_ VLLRC 66_ YTCKS 71_ LPRDE 76_ RCNLT 81_ QNCSH 86_ GQTCT 91_ TLIAH 96_ GNTES 101_ GLLTT 106_ HSTWC 111_ TDSCQ 116_ PITKT 121_ VEGTQ 126_ VTMTC 131_ CQSSL 136_ CNVPP 141_ WQSSR 146_ VQDPT 151_ GKGAG 156_ GPRGS 161_ SETVG 166_ AALLL 171_ NLLAG 176_LGAMG
1: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity)