Purine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28)
1_MAEAV 6_ LIDLF 11_ GLKLN 16_ SQKNC 21_ HQTLL 26_ KTLNA 31_ VQYHH 36_ AAKAK 41_ FLCIM 46_ CCSNI 51_ SYERD 56_ GEQDN 61_ CEIET 66_ SNGLS 71_ ALLEE 76_ FEIVS 81_ CPSMA 86_ ATLYT 91_ IKQKI 96_ DEKNL 101_ SSIKV 106_ IVPRH 111_ RKTLM 116_ KAFID 121_ QLFTD 126_ VYNFE 131_ FEDLQ 136_ VTFRG 141_ GLFKQ 146_ SIEIN 151_ VITAQ 156_ ELRGI 161_ QNEIE 166_ TFLRS 171_ LPALR 176_ GKLTI 181_ ITSSL 186_ IPDIF 191_ IHGFT 196_ TRTGG 201_ ISYIP 206_ TLSSF 211_ NLFSS 216_ SKRRD 221_ PKVVV 226_ QENLR 231_ RLANA 236_ AGFNV 241_ EKFYR 246_ IKTHH 251_ SNDIW 256_ IMGRK 261_ EPDSY 266_ DGITT 271_ NQRGV 276_ TIAAL 281_ GADCI 286_ PIVFA 291_ DPVKK 296_ ACGVA 301_ HAGWK 306_ GTLLG 311_ VAMAT 316_ VNAMI 321_ AEYGC 326_ SLEDI 331_ VVVLG 336_ PSVGP 341_ CCFTL 346_ PRESA 351_ EAFHN 356_ LHPAC 361_ VQLFD 366_ SPNPC 371_ IDIRK 376_ ATRIL 381_ LEQGG 386_ ILPQN 391_ IQDQN 396_ QDLNL 401_ CTSCH 406_ PDKFF 411_ SHVRD 416_ GLNFG 421_TQIGF
1: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345). Also has adenosine deaminase activity (PubMed:31978345). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558). Does not show laccase activity (PubMed:27959965, PubMed:31978345)