Inactive serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3)
1_MISFC 6_ PDCGK 11_ SIQAA 16_ FKFCP 21_ YCGNS 26_ LPVEE 31_ HVGSQ 36_ TFVNP 41_ HVSSF 46_ QGSKR 51_ GLNSS 56_ FETSP 61_ KKVKW 66_ SSTVT 71_ SPRLS 76_ LFSDG 81_ DSSES 86_ EDTLS 91_ SSERS 96_ KGSGS 101_ RPPTP 106_ KSSPQ 111_ KTRKS 116_ PQVTR 121_ GSPQK 126_ TSCSP 131_ QKTRQ 136_ SPQTL 141_ KRSRV 146_ TTSLE 151_ ALPTG 156_ TVLTD 161_ KSGRQ 166_ WKLKS 171_ FQTRD 176_ NQGIL 181_ YEAAP 186_ TSTLT 191_ CDSGP 196_ QKQKF 201_ SLKLD 206_ AKDGR 211_ LFNEQ 216_ NFFQR 221_ AAKPL 226_ QVNKW 231_ KKLYS 236_ TPLLA 241_ IPTCM 246_ GFGVH 251_ QDKYR 256_ FLVLP 261_ SLGRS 266_ LQSAL 271_ DVSPK 276_ HVLSE 281_ RSVLQ 286_ VACRL 291_ LDALE 296_ FLHEN 301_ EYVHG 306_ NVTAE 311_ NIFVD 316_ PEDQS 321_ QVTLA 326_ GYGFA 331_ FRYCP 336_ SGKHV 341_ AYVEG 346_ SRSPH 351_ EGDLE 356_ FISMD 361_ LHKGC 366_ GPSRR 371_ SDLQS 376_ LGYCM 381_ LKWLY 386_ GFLPW 391_ TNCLP 396_ NTEDI 401_ MKQKQ 406_ KFVDK 411_ PGPFV 416_ GPCGH 421_ WIRPS 426_ ETLQK 431_ YLKVV 436_ MALTY 441_ EEKPP 446_ YAMLR 451_ NNLEA 456_ LLQDL 461_ RVSPY 466_DPIGL
1: Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812)