Rho guanine nucleotide exchange factor TIAM2 (SIF and TIAM1-like exchange factor) (T-lymphoma invasion and metastasis-inducing protein 2) (TIAM-2)
1_MGNSD 6_ SQYTL 11_ QGSKN 16_ HSNTI 21_ TGAKQ 26_ IPCSL 31_ KIRGI 36_ HAKEE 41_ KSLHG 46_ WGHGS 51_ NGAGY 56_ KSRSL 61_ ARSCL 66_ SHFKS 71_ NQPYA 76_ SRLGG 81_ PTCKV 86_ SRGVA 91_ YSTHR 96_ TNAPG 101_ KDFQG 106_ ISAAF 111_ STENG 116_ FHSVG 121_ HELAD 126_ NHITS 131_ RDCNG 136_ HLLNC 141_ YGRNE 146_ SIAST 151_ PPGED 156_ RKSPR 161_ VLIKT 166_ LGKLD 171_ GCLRV 176_ EFHNG 181_ GNPSK 186_ VPAED 191_ CSEPV 196_ QLLRY 201_ SPTLA 206_ SETSP 211_ VPEAR 216_ RGSSA 221_ DSLPS 226_ HRPSP 231_ TDSRL 236_ RSSKG 241_ SSLSS 246_ ESSWY 251_ DSPWG 256_ NAGEL 261_ SEAEG 266_ SFLAP 271_ GMPDP 276_ SLHAS 281_ FPPGD 286_ AKKPF 291_ NQSSS 296_ LSSLR 301_ ELYKD 306_ ANLGS 311_ LSPSG 316_ IRLSD 321_ EYMGT 326_ HASLS 331_ NRVSF 336_ ASDID 341_ VPSRV 346_ AHGDP 351_ IQYSS 356_ FTLPC 361_ RKPKA 366_ FVEDT 371_ AKKDS 376_ LKARM 381_ RRISD 386_ WTGSL 391_ SRKKR 396_ KLQEP 401_ RSKEG 406_ SDYFD 411_ SRSDG 416_ LNTDV 421_ QGSSQ 426_ ASAFL 431_ WSGGS 436_ TQILS 441_ QRSES 446_ THAIG 451_ SDPLR 456_ QNIYE 461_ NFMRE 466_ LEMSR 471_ TNTEN 476_ IETST 481_ ETAES 486_ SSESL 491_ SSLEQ 496_ LDLLF 501_ EKEQG 506_ VVRKA 511_ GWLFF 516_ KPLVT 521_ VQKER 526_ KLELV 531_ ARRKW 536_ KQYWV 541_ TLKGC 546_ TLLFY 551_ ETYGK 556_ NSMDQ 561_ SSAPR 566_ CALFA 571_ EDSIV 576_ QSVPE 581_ HPKKE 586_ NVFCL 591_ SNSFG 596_ DVYLF 601_ QATSQ 606_ TDLEN 611_ WVTAV 616_ HSACA 621_ SLFAK 626_ KHGKE 631_ DTLRL 636_ LKNQT 641_ KNLLQ 646_ KIDMD 651_ SKMKK 656_ MAELQ 661_ LSVVS 666_ DPKNR 671_ KAIEN 676_ QIQQW 681_ EQNLE 686_ KFHMD 691_ LFRMR 696_ CYLAS 701_ LQGGE 706_ LPNPK 711_ SLLAA 716_ ASRPS 721_ KLALG 726_ RLGIL 731_ SVSSF 736_ HALVC 741_ SRDDS 746_ ALRKR 751_ TLSLT 756_ QRGRN 761_ KKGIF 766_ SSLKG 771_ LDTLA 776_ RKGKE 781_ KRPSI 786_ TQVDE 791_ LLHIY 796_ GSTVD 801_ GVPRD 806_ NAWEI 811_ QTYVH 816_ FQDNH 821_ GVTVG 826_ IKPEH 831_ RVEDI 836_ LTLAC 841_ KMRQL 846_ EPSHY 851_ GLQLR 856_ KLVDD 861_ NVEYC 866_ IPAPY 871_ EYMQQ 876_ QVYDE 881_ IEVFP 886_ LNVYD 891_ VQLTK 896_ TGSVC 901_ DFGFA 906_ VTAQV 911_ DERQH 916_ LSRIF 921_ ISDVL 926_ PDGLA 931_ YGEGL 936_ RKGNE 941_ IMTLN 946_ GEAVS 951_ DLDLK 956_ QMEAL 961_ FSEKS 966_ VGLTL 971_ IARPP 976_ DTKAT 981_ LCTSW 986_ SDSDL 991_ FSRDQ 996_ KSLLP 1001_ PPNQS 1006_ QLLEE 1011_ FLDNF 1016_ KKNTA 1021_ NDFSN 1026_ VPDIT 1031_ TGLKR 1036_ SQTDG 1041_ TLDQV 1046_ SHREK 1051_ MEQTF 1056_ RSAEQ 1061_ ITALC 1066_ RSFND 1071_ SQANG 1076_ MEGPR 1081_ ENQDP 1086_ PPRSL 1091_ ARHLS 1096_ DADRL 1101_ RKVIQ 1106_ ELVDT 1111_ EKSYV 1116_ KDLSC 1121_ LFELY 1126_ LEPLQ 1131_ NETFL 1136_ TQDEM 1141_ ESLFG 1146_ SLPEM 1151_ LEFQK 1156_ VFLET 1161_ LEDGI 1166_ SASSD 1171_ FNTLE 1176_ TPSQF 1181_ RKLLF 1186_ SLGGS 1191_ FLYYA 1196_ DHFKL 1201_ YSGFC 1206_ ANHIK 1211_ VQKVL 1216_ ERAKT 1221_ DKAFK 1226_ AFLDA 1231_ RNPTK 1236_ QHSST 1241_ LESYL 1246_ IKPVQ 1251_ RVLKY 1256_ PLLLK 1261_ ELVSL 1266_ TDQES 1271_ EEHYH 1276_ LTEAL 1281_ KAMEK 1286_ VASHI 1291_ NEMQK 1296_ IYEDY 1301_ GTVFD 1306_ QLVAE 1311_ QSGTE 1316_ KEVTE 1321_ LSMGE 1326_ LLMHS 1331_ TVSWL 1336_ NPFLS 1341_ LGKAR 1346_ KDLEL 1351_ TVFVF 1356_ KRAVI 1361_ LVYKE 1366_ NCKLK 1371_ KKLPS 1376_ NSRPA 1381_ HNSTD 1386_ LDPFK 1391_ FRWLI 1396_ PISAL 1401_ QVRLG 1406_ NPAGT 1411_ ENNSI 1416_ WELIH 1421_ TKSEI 1426_ EGRPE 1431_ TIFQL 1436_ CCSDS 1441_ ESKTN 1446_ IVKVI 1451_ RSILR 1456_ ENFRR 1461_ HIKCE 1466_ LPLEK 1471_ TCKDR 1476_ LVPLK 1481_ NRVPV 1486_ SAKLA 1491_ SSRSL 1496_ KVLKN 1501_ SSSNE 1506_ WTGET 1511_ GKGTL 1516_ LDSDE 1521_ GSLSS 1526_ GTQSS 1531_ GCPTA 1536_ EGRQD 1541_ SKSTS 1546_ PGKYP 1551_ HPGLA 1556_ DFADN 1561_ LIKES 1566_ DILSD 1571_ EDDDH 1576_ RQTVK 1581_ QGSPT 1586_ KDIEI 1591_ QFQRL 1596_ RISED 1601_ PDVHP 1606_ EAEQQ 1611_ PGPES 1616_ GEGQK 1621_ GGEQP 1626_ KLVRG 1631_ HFCPI 1636_ KRKAN 1641_ STKRD 1646_ RGTLL 1651_ KAQIR 1656_ HQSLD 1661_ SQSEN 1666_ ATIDL 1671_ NSVLE 1676_ REFSV 1681_ QSLTS 1686_ VVSEE 1691_ CFYET 1696_ESHGK
1: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA