Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
1_MNPGF 6_ DLSRR 11_ NPQED 16_ FELIQ 21_ RIGSG 26_ TYGDV 31_ YKARN 36_ VNTGE 41_ LAAIK 46_ VIKLE 51_ PGEDF 56_ AVVQQ 61_ EIIMM 66_ KDCKH 71_ PNIVA 76_ YFGSY 81_ LRRDK 86_ LWICM 91_ EFCGG 96_ GSLQD 101_ IYHVT 106_ GPLSE 111_ LQIAY 116_ VSRET 121_ LQGLY 126_ YLHSK 131_ GKMHR 136_ DIKGA 141_ NILLT 146_ DNGHV 151_ KLADF 156_ GVSAQ 161_ ITATI 166_ AKRKS 171_ FIGTP 176_ YWMAP 181_ EVAAV 186_ ERKGG 191_ YNQLC 196_ DLWAV 201_ GITAI 206_ ELAEL 211_ QPPMF 216_ DLHPM 221_ RALFL 226_ MTKSN 231_ FQPPK 236_ LKDKM 241_ KWSNS 246_ FHHFV 251_ KMALT 256_ KNPKK 261_ RPTAE 266_ KLLQH 271_ PFVTQ 276_ HLTRS 281_ LAIEL 286_ LDKVN 291_ NPDHS 296_ TYHDF 301_ DDDDP 306_ EPLVA 311_ VPHRI 316_ HSTSR 321_ NVREE 326_ KTRSE 331_ ITFGQ 336_ VKFDP 341_ PLRKE 346_ TEPHH 351_ ELPDS 356_ DGFLD 361_ SSEEI 366_ YYTAR 371_ SNLDL 376_ QLEYG 381_ QGHQG 386_ GYFLG 391_ ANKSL 396_ LKSVE 401_ EELHQ 406_ RGHVA 411_ HLEDD 416_ EGDDD 421_ ESKHS 426_ TLKAK 431_ IPPPL 436_ PPKPK 441_ SIFIP 446_ QEMHS 451_ TEDEN 456_ QGTIK 461_ RCPMS 466_ GSPAK 471_ PSQVP 476_ PRPPP 481_ PRLPP 486_ HKPVA 491_ LGNGM 496_ SSFQL 501_ NGERD 506_ GSLCQ 511_ QQNEH 516_ RGTNL 521_ SRKEK 526_ KDVPK 531_ PISNG 536_ LPPTP 541_ KVHMG 546_ ACFSK 551_ VFNGC 556_ PLKIH 561_ CASSW 566_ INPDT 571_ RDQYL 576_ IFGAE 581_ EGIYT 586_ LNLNE 591_ LHETS 596_ MEQLF 601_ PRRCT 606_ WLYVM 611_ NNCLL 616_ SISGK 621_ ASQLY 626_ SHNLP 631_ GLFDY 636_ ARQMQ 641_ KLPVA 646_ IPAHK 651_ LPDRI 656_ LPRKF 661_ SVSAK 666_ IPETK 671_ WCQKC 676_ CVVRN 681_ PYTGH 686_ KYLCG 691_ ALQTS 696_ IVLLE 701_ WVEPM 706_ QKFML 711_ IKHID 716_ FPIPC 721_ PLRMF 726_ EMLVV 731_ PEQEY 736_ PLVCV 741_ GVSRG 746_ RDFNQ 751_ VVRFE 756_ TVNPN 761_ STSSW 766_ FTESD 771_ TPQTN 776_ VTHVT 781_ QLERD 786_ TILVC 791_ LDCCI 796_ KIVNL 801_ QGRLK 806_ SSRKL 811_ SSELT 816_ FDFQI 821_ ESIVC 826_ LQDSV 831_ LAFWK 836_ HGMQG 841_ RSFRS 846_ NEVTQ 851_ EISDS 856_ TRIFR 861_ LLGSD 866_ RVVVL 871_ ESRPT 876_ DNPTA 881_ NSNLY 886_ILAGH
1: Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443)