Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 21) (DHHC-21) (Zinc finger DHHC domain-containing protein 21)
1_MGLRI 6_ HFVVD 11_ PHGWC 16_ CMGLI 21_ VFVWL 26_ YNIVL 31_ IPKIV 36_ LFPHY 41_ EEGHI 46_ PGILI 51_ IIFYG 56_ ISIFC 61_ LVALV 66_ RASIT 71_ DPGRL 76_ PENPK 81_ IPHGE 86_ REFWE 91_ LCNKC 96_ NLMRP 101_ KRSHH 106_ CSRCG 111_ HCVRR 116_ MDHHC 121_ PWINN 126_ CVGED 131_ NHWLF 136_ LQLCF 141_ YTELL 146_ TCYAL 151_ MFSFC 156_ HYYYF 161_ LPLKK 166_ RNLDL 171_ FVFRH 176_ ELAIM 181_ RLAAF 186_ MGITM 191_ LVGIT 196_ GLFYT 201_ QLIGI 206_ ITDTT 211_ SIEKM 216_ SNCCE 221_ DISRP 226_ RKPWQ 231_ QTFSE 236_ VFGTR 241_ WKILW 246_ FIPFR 251_ QRQPL 256_RVPYH
1: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (PubMed:22031296). This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (PubMed:22031296). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Also has a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity)