Kinase suppressor of Ras 1 (EC 2.7.11.1)
1_MDRAA 6_ LRAAA 11_ MGEKK 16_ EGGGG 21_ GDAAA 26_ AEGGA 31_ GAAAS 36_ RALQQ 41_ CGQLQ 46_ KLIDI 51_ SIGSL 56_ RGLRT 61_ KCAVS 66_ NDLTQ 71_ QEIRT 76_ LEAKL 81_ VRYIC 86_ KQRQC 91_ KLSVA 96_ PGERT 101_ PELNS 106_ YPRFS 111_ DWLYT 116_ FNVRP 121_ EVVQE 126_ IPRDL 131_ TLDAL 136_ LEMNE 141_ AKVKE 146_ TLRRC 151_ GASGD 156_ ECGRL 161_ QYALT 166_ CLRKV 171_ TGLGG 176_ EHKED 181_ SSWSS 186_ LDARR 191_ ESGSG 196_ PSTDT 201_ LSAAS 206_ LPWPP 211_ GSSQL 216_ GRAGN 221_ SAQGP 226_ RSISV 231_ SALPA 236_ SDSPT 241_ PSFSE 246_ GLSDT 251_ CIPLH 256_ ASGRL 261_ TPRAL 266_ HSFIT 271_ PPTTP 276_ QLRRH 281_ TKLKP 286_ PRTPP 291_ PPSRK 296_ VFQLL 301_ PSFPT 306_ LTRSK 311_ SHESQ 316_ LGNRI 321_ DDVSS 326_ MRFDL 331_ SHGSP 336_ QMVRR 341_ DIGLS 346_ VTHRF 351_ STKSW 356_ LSQVC 361_ HVCQK 366_ SMIFG 371_ VKCKH 376_ CRLKC 381_ HNKCT 386_ KEAPA 391_ CRISF 396_ LPLTR 401_ LRRTE 406_ SVPSD 411_ INNPV 416_ DRAAE 421_ PHFGT 426_ LPKAL 431_ TKKEH 436_ PPAMN 441_ HLDSS 446_ SNPSS 451_ TTSST 456_ PSSPA 461_ PFPTS 466_ SNPSS 471_ ATTPP 476_ NPSPG 481_ QRDSR 486_ FNFPA 491_ AYFIH 496_ HRQQF 501_ IFPVP 506_ SAGHC 511_ WKCLL 516_ IAESL 521_ KENAF 526_ NISAF 531_ AHAAP 536_ LPEAA 541_ DGTRL 546_ DDQPK 551_ ADVLE 556_ AHEAE 561_ AEEPE 566_ AGKSE 571_ AEDDE 576_ DEVDD 581_ LPSSR 586_ RPWRG 591_ PISRK 596_ ASQTS 601_ VYLQE 606_ WDIPF 611_ EQVEL 616_ GEPIG 621_ QGRWG 626_ RVHRG 631_ RWHGE 636_ VAIRL 641_ LEMDG 646_ HNQDH 651_ LKLFK 656_ KEVMN 661_ YRQTR 666_ HENVV 671_ LFMGA 676_ CMNPP 681_ HLAII 686_ TSFCK 691_ GRTLH 696_ SFVRD 701_ PKTSL 706_ DINKT 711_ RQIAQ 716_ EIIKG 721_ MGYLH 726_ AKGIV 731_ HKDLK 736_ SKNVF 741_ YDNGK 746_ VVITD 751_ FGLFG 756_ ISGVV 761_ REGRR 766_ ENQLK 771_ LSHDW 776_ LCYLA 781_ PEIVR 786_ EMTPG 791_ KDEDQ 796_ LPFSK 801_ AADVY 806_ AFGTV 811_ WYELQ 816_ ARDWP 821_ LKNQA 826_ AEASI 831_ WQIGS 836_ GEGMK 841_ RVLTS 846_ VSLGK 851_ EVSEI 856_ LSACW 861_ AFDLQ 866_ ERPSF 871_ SLLMD 876_ MLEKL 881_ PKLNR 886_ RLSHP 891_ GHFWK 896_ SADIN 901_ SSKVV 906_ PRFER 911_ FGLGV 916_LESSN
1: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity)