Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog)
1_MCARG 6_ QVGRG 11_ TQLRT 16_ GRPCS 21_ QVPGS 26_ RWRPE 31_ RLLRR 36_ QRAGG 41_ RPSRP 46_ HPARA 51_ RPGLS 56_ LPATL 61_ LGSRA 66_ AAAVP 71_ LPLPP 76_ ALAPG 81_ DPAMP 86_ VRTEC 91_ PPPAG 96_ ASAAS 101_ AASLI 106_ PPPPI 111_ NTQQP 116_ GVATS 121_ LLYSG 126_ SKFRG 131_ HQKSK 136_ GNSYD 141_ VEVVL 146_ QHVDT 151_ GNSYL 156_ CGYLK 161_ IKGLT 166_ EEYPT 171_ LTTFF 176_ EGEII 181_ SKKHP 186_ FLTRK 191_ WDADE 196_ DVDRK 201_ HWGKF 206_ LAFYQ 211_ YAKSF 216_ NSDDF 221_ DYEEL 226_ KNGDY 231_ VFMRW 236_ KEQFL 241_ VPDHT 246_ IKDIS 251_ GASFA 256_ GFYYI 261_ CFQKS 266_ AASIE 271_ GYYYH 276_ RSSEW 281_ YQSLN 286_ LTHVP 291_EHSAP
1: Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) (PubMed:29911972). Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp (PubMed:29632410). Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue (PubMed:29632410)