Sphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2)
1_MMCLE 6_ CASAA 11_ AGGAE 16_ EEEAD 21_ AERRR 26_ RRRGA 31_ QRGAG 36_ GSGCC 41_ GARGA 46_ GGAGV 51_ SAAGD 56_ EVQTL 61_ SGSVR 66_ RAPTG 71_ PPGTP 76_ GTPGC 81_ AATAK 86_ GPGAQ 91_ QPKPA 96_ SLGRG 101_ RGAAA 106_ AILSL 111_ GNVLN 116_ YLDRY 121_ TVAGV 126_ LLDIQ 131_ QHFGV 136_ KDRGA 141_ GLLQS 146_ VFICS 151_ FMVAA 156_ PIFGY 161_ LGDRF 166_ NRKVI 171_ LSCGI 176_ FFWSA 181_ VTFSS 186_ SFIPQ 191_ QYFWL 196_ LVLSR 201_ GLVGI 206_ GEASY 211_ STIAP 216_ TIIGD 221_ LFTKN 226_ TRTLM 231_ LSVFY 236_ FAIPL 241_ GSGLG 246_ YITGS 251_ SVKQA 256_ AGDWH 261_ WALRV 266_ SPVLG 271_ MITGT 276_ LILIL 281_ VPATK 286_ RGHAD 291_ QLGDQ 296_ LKART 301_ SWLRD 306_ MKALI 311_ RNRSY 316_ VFSSL 321_ ATSAV 326_ SFATG 331_ ALGMW 336_ IPLYL 341_ HRAQV 346_ VQKTA 351_ ETCNS 356_ PPCGA 361_ KDSLI 366_ FGAIT 371_ CFTGF 376_ LGVVT 381_ GAGAT 386_ RWCRL 391_ KTQRA 396_ DPLVC 401_ AVGML 406_ GSAIF 411_ ICLIF 416_ VAAKS 421_ SIVGA 426_ YICIF 431_ VGETL 436_ LFSNW 441_ AITAD 446_ ILMYV 451_ VIPTR 456_ RATAV 461_ ALQSF 466_ TSHLL 471_ GDAGS 476_ PYLIG 481_ FISDL 486_ IRQST 491_ KDSPL 496_ WEFLS 501_ LGYAL 506_ MLCPF 511_ VVVLG 516_ GMFFL 521_ ATALF 526_ FVSDR 531_ ARAEQ 536_ QVNQL 541_AMPPA
1: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:19074308, PubMed:21084291, PubMed:23180825). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:19074308, PubMed:23180825). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:19074308, PubMed:23180825). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (By similarity). Also required for the egress of immature B-cells from the bone marrow (By similarity). In contrast, not involved in S1P release from red blood cells (By similarity). Involved in auditory function (PubMed:30973865). S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (By similarity). In addition to export, also able to mediate S1P import (By similarity)