Gene name: SIAH3

Uniprot entry:

Q8IW03

Protein names:

Seven in absentia homolog 3 (Siah-3)

Protein sequence:

1_MLFFT 6_ QCFGA 11_ VLDLI 16_ HLRFQ 21_ HYKAK 26_ RVFSA 31_ AGQLV 36_ CVVNP 41_ THNLK 46_ YVSSR 51_ RAVTQ 56_ SAPEQ 61_ GSFHP 66_ HHLSH 71_ HHCHH 76_ RHHHH 81_ LRHHA 86_ HPHHL 91_ HHQEA 96_ GLHAN 101_ PVTPC 106_ LCMCP 111_ LFSCQ 116_ WEGRL 121_ EVVVP 126_ HLRQI 131_ HRVDI 136_ LQGAE 141_ IVFLA 146_ TDMHL 151_ PAPAD 156_ WIIMH 161_ SCLGH 166_ HFLLV 171_ LRKQE 176_ RHEGH 181_ PQFFA 186_ TMMLI 191_ GTPTQ 196_ ADCFT 201_ YRLEL 206_ NRNHR 211_ RLKWE 216_ ATPRS 221_ VLECV 226_ DSVIT 231_ DGDCL 236_ VLNTS 241_ LAQLF 246_ SDNGS 251_ LAIGI 256_ AITAT 261_EVLPS

Protein annotations

Protein functions:

1: Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria