Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)
1_MSGGF 6_ ELQPR 11_ DGGPR 16_ VALAP 21_ GETVI 26_ GRGPL 31_ LGITD 36_ KRVSR 41_ RHAIL 46_ EVAGG 51_ QLRIK 56_ PIHTN 61_ PCFYQ 66_ SSEKS 71_ QLLPL 76_ KPNLW 81_ CYLNP 86_ GDSFS 91_ LLVDK 96_ YIFRI 101_ LSIPS 106_ EVEMQ 111_ CTLRN 116_ SQVLD 121_ EDNIL 126_ NETPK 131_ SPVIN 136_ LPHET 141_ TGASQ 146_ LEGST 151_ EIAKT 156_ QMTPT 161_ NSVSF 166_ LGENR 171_ DCNKQ 176_ QPILA 181_ ERKRI 186_ LPTWM 191_ LAEHL 196_ SDQNL 201_ SVPAI 206_ SGGNV 211_ IQGSG 216_ KEEIC 221_ KDKSQ 226_ LNTTQ 231_ QGRRQ 236_ LISSG 241_ SSENT 246_ SAEQD 251_ TGEEC 256_ KNTDQ 261_ EESTI 266_ SSKEM 271_ PQSFS 276_ AITLS 281_ NTEMN 286_ NIKTN 291_ AQRNK 296_ LPIEE 301_ LGKVS 306_ KHKIA 311_ TKRTP 316_ HKEDE 321_ AMSCS 326_ ENCSS 331_ AQGDS 336_ LQDES 341_ QGSHS 346_ ESSSN 351_ PSNPE 356_ TLHAK 361_ ATDSV 366_ LQGSE 371_ GNKVK 376_ RTSCM 381_ YGANC 386_ YRKNP 391_ VHFQH 396_ FSHPG 401_ DSDYG 406_ GVQIV 411_ GQDET 416_ DDRPE 421_ CPYGP 426_ SCYRK 431_ NPQHK 436_ IEYRH 441_ NTLPV 446_ RNVLD 451_ EDNDN 456_ VGQPN 461_ EYDLN 466_ DSFLD 471_ DEEED 476_ YEPTD 481_ EDSDW 486_ EPGKE 491_ DEEKE 496_ DVEEL 501_ LKEAK 506_RFMKR
1: Histone chaperone involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:21211722, PubMed:29905837, PubMed:30104678). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:30104678). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:21211722, PubMed:29905837, PubMed:30104678). Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro (PubMed:17353262, PubMed:17396150). Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (PubMed:17353262, PubMed:17396150). Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (PubMed:21211721, PubMed:23689425). Also acts as a negative regulator of cell pluripotency by promoting histone exchange (By similarity). Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity)