MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
1_MSEES 6_ DMDKA 11_ IKETS 16_ ILEEY 21_ SINWT 26_ QKLGA 31_ GISGP 36_ VRVCV 41_ KKSTQ 46_ ERFAL 51_ KILLD 56_ RPKAR 61_ NEVRL 66_ HMMCA 71_ THPNI 76_ VQIIE 81_ VFANS 86_ VQFPH 91_ ESSPR 96_ ARLLI 101_ VMEMM 106_ EGGEL 111_ FHRIS 116_ QHRHF 121_ TEKQA 126_ SQVTK 131_ QIALA 136_ LRHCH 141_ LLNIA 146_ HRDLK 151_ PENLL 156_ FKDNS 161_ LDAPV 166_ KLCDF 171_ GFAKI 176_ DQGDL 181_ MTPQF 186_ TPYYV 191_ APQVL 196_ EAQRR 201_ HQKEK 206_ SGIIP 211_ TSPTP 216_ YTYNK 221_ SCDLW 226_ SLGVI 231_ IYVML 236_ CGYPP 241_ FYSKH 246_ HSRTI 251_ PKDMR 256_ RKIMT 261_ GSFEF 266_ PEEEW 271_ SQISE 276_ MAKDV 281_ VRKLL 286_ KVKPE 291_ ERLTI 296_ EGVLD 301_ HPWLN 306_ STEAL 311_ DNVLP 316_ SAQLM 321_ MDKAV 326_ VAGIQ 331_ QAHAE 336_ QLANM 341_ RIQDL 346_ KVSLK 351_ PLHSV 356_ NNPIL 361_ RKRKL 366_ LGTKP 371_ KDSVY 376_ IHDHE 381_ NGAED 386_ SNVAL 391_ EKLRD 396_ VIAQC 401_ ILPQA 406_ GKGEN 411_ EDEKL 416_ NEVMQ 421_ EAWKY 426_ NRECK 431_ LLRDT 436_ LQSFS 441_ WNGRG 446_ FTDKV 451_ DRLKL 456_ AEIVK 461_ QVIEE 466_QTTSH
1: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement