Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
1_MAEPV 6_ SPLKH 11_ FVLAK 16_ KAITA 21_ IFDQL 26_ LEFVT 31_ EGSHF 36_ VEATY 41_ KNPEL 46_ DRIAT 51_ EDDLV 56_ EMQGY 61_ KDKLS 66_ IIGEV 71_ LSRRH 76_ MKVAF 81_ FGRTS 86_ SGKSS 91_ VINAM 96_ LWDKV 101_ LPSGI 106_ GHITN 111_ CFLSV 116_ EGTDG 121_ DKAYL 126_ MTEGS 131_ DEKKS 136_ VKTVN 141_ QLAHA 146_ LHMDK 151_ DLKAG 156_ CLVRV 161_ FWPKA 166_ KCALL 171_ RDDLV 176_ LVDSP 181_ GTDVT 186_ TELDS 191_ WIDKF 196_ CLDAD 201_ VFVLV 206_ ANSES 211_ TLMNT 216_ EKHFF 221_ HKVNE 226_ RLSKP 231_ NIFIL 236_ NNRWD 241_ ASASE 246_ PEYME 251_ DVRRQ 256_ HMERC 261_ LHFLV 266_ EELKV 271_ VNALE 276_ AQNRI 281_ FFVSA 286_ KEVLS 291_ ARKQK 296_ AQGMP 301_ ESGVA 306_ LAEGF 311_ HARLQ 316_ EFQNF 321_ EQIFE 326_ ECISQ 331_ SAVKT 336_ KFEQH 341_ TIRAK 346_ QILAT 351_ VKNIM 356_ DSVNL 361_ AAEDK 366_ RHYSV 371_ EERED 376_ QIDRL 381_ DFIRN 386_ QMNLL 391_ TLDVK 396_ KKIKE 401_ VTEEV 406_ ANKVS 411_ CAMTD 416_ EICRL 421_ SVLVD 426_ EFCSE 431_ FHPNP 436_ DVLKI 441_ YKSEL 446_ NKHIE 451_ DGMGR 456_ NLADR 461_ CTDEV 466_ NALVL 471_ QTQQE 476_ IIENL 481_ KPLLP 486_ AGIQD 491_ KLHTL 496_ IPCKK 501_ FDLSY 506_ NLNYH 511_ KLCSD 516_ FQEDI 521_ VFRFS 526_ LGWSS 531_ LVHRF 536_ LGPRN 541_ AQRVL 546_ LGLSE 551_ PIFQL 556_ PRSLA 561_ STPTA 566_ PTTPA 571_ TPDNA 576_ SQEEL 581_ MITLV 586_ TGLAS 591_ VTSRT 596_ SMGII 601_ IVGGV 606_ IWKTI 611_ GWKLL 616_ SVSLT 621_ MYGAL 626_ YLYER 631_ LSWTT 636_ HAKER 641_ AFKQQ 646_ FVNYA 651_ TEKLR 656_ MIVSS 661_ TSANC 666_ SHQVK 671_ QQIAT 676_ TFARL 681_ CQQVD 686_ ITQKQ 691_ LEEEI 696_ ARLPK 701_ EIDQL 706_ EKIQN 711_ NSKLL 716_ RNKAV 721_ QLENE 726_ LENFT 731_ KQFLP 736_SSNEE
1: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303)