WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)
1_MAAEI 6_ HSRPQ 11_ SSRPV 16_ LLSKI 21_ EGHQD 26_ AVTAA 31_ LLIPK 36_ EDGVI 41_ TASED 46_ RTIRV 51_ WLKRD 56_ SGQYW 61_ PSIYH 66_ TMASP 71_ CSAMA 76_ YHHDS 81_ RRIFV 86_ GQDNG 91_ AVMEF 96_ HVSED 101_ FNKMN 106_ FIKTY 111_ PAHQN 116_ RVSAI 121_ IFSLA 126_ TEWVI 131_ STGHD 136_ KCVSW 141_ MCTRS 146_ GNMLG 151_ RHFFT 156_ SWASC 161_ LQYDF 166_ DTQYA 171_ FVGDY 176_ SGQIT 181_ LLKLE 186_ QNTCS 191_ VITTL 196_ KGHEG 201_ SVACL 206_ WWDPI 211_ QRLLF 216_ SGASD 221_ NSIIM 226_ WDIGG 231_ RKGRT 236_ LLLQG 241_ HHDKV 246_ QSLCY 251_ LQLTR 256_ QLVSC 261_ SSDGG 266_ IAVWN 271_ MDVSR 276_ EEAPQ 281_ WLESD 286_ SCQKC 291_ EQPFF 296_ WNIKQ 301_ MWDTK 306_ TLGLR 311_ QHHCR 316_ KCGQA 321_ VCGKC 326_ SSKRS 331_ SYPVM 336_ GFEFQ 341_ VRVCD 346_ SCYDS 351_ IKDED 356_ RTSLA 361_ TFHEG 366_ KHNIS 371_ HMSMD 376_ IARGL 381_ MVTCG 386_ TDRIV 391_ KIWDM 396_ TPVVG 401_CSLAT
1: Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436)