DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
1_MGQCV 6_ TKCKN 11_ PSSTL 16_ GSKNG 21_ DREPS 26_ NKSHS 31_ RRGAG 36_ HREEQ 41_ VPPCG 46_ KPGGD 51_ ILVNG 56_ TKKAE 61_ AATEA 66_ CQLPT 71_ SSGDA 76_ GRESK 81_ SNAEE 86_ SSLQR 91_ LEELF 96_ RRYKD 101_ EREDA 106_ ILEEG 111_ MERFC 116_ NDLCV 121_ DPTEF 126_ RVLLL 131_ AWKFQ 136_ AATMC 141_ KFTRK 146_ EFFDG 151_ CKAIS 156_ ADSID 161_ GICAR 166_ FPSLL 171_ TEAKQ 176_ EDKFK 181_ DLYRF 186_ TFQFG 191_ LDSEE 196_ GQRSL 201_ HREIA 206_ IALWK 211_ LVFTQ 216_ NNPPV 221_ LDQWL 226_ NFLTE 231_ NPSGI 236_ KGISR 241_ DTWNM 246_ FLNFT 251_ QVIGP 256_ DLSNY 261_ SEDEA 266_ WPSLF 271_ DTFVE 276_ WEMER 281_ RKREG 286_ EGRGA 291_ LSSGP 296_EGLCP
1: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:18823379, PubMed:19617556, PubMed:23201271, PubMed:27542266). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:25349211, PubMed:26906416)