Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)
1_MEPGE 6_ VKDRI 11_ LENIS 16_ LSVKK 21_ LQSYF 26_ AACED 31_ EIPAI 36_ RNHDK 41_ VLQRL 46_ CEHLD 51_ HALLY 56_ GLQDL 61_ SSGYW 66_ VLVVH 71_ FTRRE 76_ AIKQI 81_ EVLQH 86_ VATNL 91_ GRSRA 96_ WLYLA 101_ LNENS 106_ LESYL 111_ RLFQE 116_ NLGLL 121_ HKYYV 126_ KNALV 131_ CSHDH 136_ LTLFL 141_ TLVSG 146_ LEFIR 151_ FELDL 156_ DAPYL 161_ DLAPY 166_ MPDYY 171_ KPQYL 176_ LDFED 181_ RLPSS 186_ VHGSD 191_ SLSLN 196_ SFNSV 201_ TSTNL 206_ EWDDS 211_ AIAPS 216_ SEDYD 221_ FGDVF 226_ PAVPS 231_ VPSTD 236_ WEDGD 241_ LTDTV 246_ SGPRS 251_ TASDL 256_ TSSKA 261_ STRSP 266_ TQRQN 271_ PFNEE 276_ PAETV 281_ SSSDT 286_ TPVHT 291_ TSQEK 296_ EEAQA 301_ LDPPD 306_ ACTEL 311_ EVIRV 316_ TKKKK 321_ IGKKK 326_ KSRSD 331_ EEASP 336_ LHPAC 341_ SQKKC 346_ AKQGD 351_ GDSRN 356_ GSPSL 361_ GRDSP 366_ DTMLA 371_ SPQEE 376_ GEGPS 381_ STTES 386_ SERSE 391_ PGLLI 396_ PEMKD 401_ TSMER 406_ LGQPL 411_ SKVID 416_ QLNGQ 421_ LDPST 426_ WCSRA 431_ EPPDQ 436_ SFRTG 441_ SPGDA 446_ PERPP 451_ LCDFS 456_ EGLSA 461_ PMDFY 466_ RFTVE 471_ SPSTV 476_ TSGGG 481_ HHDPA 486_ GLGQP 491_ LHVPS 496_ SPEAA 501_ GQEEE 506_ GGGGE 511_ GQTPR 516_ PLEDT 521_ TREAQ 526_ ELEAQ 531_ LSLVR 536_ EGPVS 541_ EPEPG 546_ TQEVL 551_ CQLKR 556_ DQPSP 561_ CLSSA 566_ EDSGV 571_ DEGQG 576_ SPSEM 581_ VHSSE 586_ FRVDN 591_ NHLLL 596_ LMIHV 601_ FRENE 606_ EQLFK 611_ MIRMS 616_ TGHME 621_ GNLQL 626_ LYVLL 631_ TDCYV 636_ YLLRK 641_ GATEK 646_ PYLVE 651_ EAVSY 656_ NELDY 661_ VSVGL 666_ DQQTV 671_ KLVCT 676_ NRRKQ 681_ FLLDT 686_ ADVAL 691_ AEFFL 696_ ASLKS 701_ AMIKG 706_ CREPP 711_ YPSIL 716_ TDATM 721_ EKLAL 726_ AKFVA 731_ QESKC 736_ EASAV 741_ TVRFY 746_ GLVHW 751_ EDPTD 756_ ESLGP 761_ TPCHC 766_ SPPEG 771_ TITKE 776_ GMLHY 781_ KAGTS 786_ YLGKE 791_ HWKTC 796_ FVVLS 801_ NGILY 806_ QYPDR 811_ TDVIP 816_ LLSVN 821_ MGGEQ 826_ CGGCR 831_ RANTT 836_ DRPHA 841_ FQVIL 846_ SDRPC 851_ LELSA 856_ ESEAE 861_ MAEWM 866_ QHLCQ 871_ AVSKG 876_ VIPQG 881_ VAPSP 886_ CIPCC 891_ LVLTD 896_ DRLFT 901_ CHEDC 906_ QTSFF 911_ RSLGT 916_ AKLGD 921_ ISAVS 926_ TEPGK 931_ EYCVL 936_ EFSQD 941_ SQQLL 946_ PPWVI 951_ YLSCT 956_ SELDR 961_ LLSAL 966_ NSGWK 971_ TIYQV 976_ DLPHT 981_ AIQEA 986_ SNKKK 991_ FEDAL 996_ SLIHS 1001_ AWQRS 1006_ DSLCR 1011_GRASR
1: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402)