Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]
1_MWRGR 6_ AGALL 11_ RVWGF 16_ WPTGV 21_ PRRRP 26_ LSCDA 31_ ASQAG 36_ SNYPR 41_ CWNCG 46_ GPWGP 51_ GREDR 56_ FFCPQ 61_ CRALQ 66_ APDPT 71_ RDYFS 76_ LMDCN 81_ RSFRV 86_ DTAKL 91_ QHRYQ 96_ QLQRL 101_ VHPDF 106_ FSQRS 111_ QTEKD 116_ FSEKH 121_ STLVN 126_ DAYKT 131_ LLAPL 136_ SRGLY 141_ LLKLH 146_ GIEIP 151_ ERTDY 156_ EMDRQ 161_ FLIEI 166_ MEINE 171_ KLAEA 176_ ESEAA 181_ MKEIE 186_ SIVKA 191_ KQKEF 196_ TDNVS 201_ SAFEQ 206_ DDFEE 211_ AKEIL 216_ TKMRY 221_ FSNIE 226_EKIKL
1: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria (PubMed:20668094). Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain (PubMed:26749241). Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 (PubMed:26749241). Plays an essential role in hematopoiesis (By similarity)
2: Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm (PubMed:29309586). Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1 (PubMed:29309586). This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT (PubMed:29309586)