Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)
1_MTSTG 6_ KDGGA 11_ QHAQY 16_ VGPYR 21_ LEKTL 26_ GKGQT 31_ GLVKL 36_ GVHCV 41_ TCQKV 46_ AIKIV 51_ NREKL 56_ SESVL 61_ MKVER 66_ EIAIL 71_ KLIEH 76_ PHVLK 81_ LHDVY 86_ ENKKY 91_ LYLVL 96_ EHVSG 101_ GELFD 106_ YLVKK 111_ GRLTP 116_ KEARK 121_ FFRQI 126_ ISALD 131_ FCHSH 136_ SICHR 141_ DLKPE 146_ NLLLD 151_ EKNNI 156_ RIADF 161_ GMASL 166_ QVGDS 171_ LLETS 176_ CGSPH 181_ YACPE 186_ VIRGE 191_ KYDGR 196_ KADVW 201_ SCGVI 206_ LFALL 211_ VGALP 216_ FDDDN 221_ LRQLL 226_ EKVKR 231_ GVFHM 236_ PHFIP 241_ PDCQS 246_ LLRGM 251_ IEVDA 256_ ARRLT 261_ LEHIQ 266_ KHIWY 271_ IGGKN 276_ EPEPE 281_ QPIPR 286_ KVQIR 291_ SLPSL 296_ EDIDP 301_ DVLDS 306_ MHSLG 311_ CFRDR 316_ NKLLQ 321_ DLLSE 326_ EENQE 331_ KMIYF 336_ LLLDR 341_ KERYP 346_ SQEDE 351_ DLPPR 356_ NEIDP 361_ PRKRV 366_ DSPML 371_ NRHGK 376_ RRPER 381_ KSMEV 386_ LSVTD 391_ GGSPV 396_ PARRA 401_ IEMAQ 406_ HGQRS 411_ RSISG 416_ ASSGL 421_ STSPL 426_ SSPRV 431_ TPHPS 436_ PRGSP 441_ LPTPK 446_ GTPVH 451_ TPKES 456_ PAGTP 461_ NPTPP 466_ SSPSV 471_ GGVPW 476_ RARLN 481_ SIKNS 486_ FLGSP 491_ RFHRR 496_ KLQVP 501_ TPEEM 506_ SNLTP 511_ ESSPE 516_ LAKKS 521_ WFGNF 526_ ISLEK 531_ EEQIF 536_ VVIKD 541_ KPLSS 546_ IKADI 551_ VHAFL 556_ SIPSL 561_ SHSVI 566_ SQTSF 571_ RAEYK 576_ ATGGP 581_ AVFQK 586_ PVKFQ 591_ VDITY 596_ TEGGE 601_ AQKEN 606_ GIYSV 611_ TFTLL 616_ SGPSR 621_ RFKRV 626_ VETIQ 631_ AQLLS 636_ THDPP 641_ AAQHL 646_ SDTTN 651_ CMEMM 656_ TGRLS 661_ KCGSP 666_ LSNFF 671_ DVIKQ 676_ LFSDE 681_ KNGQA 686_ AQAPS 691_ TPAKR 696_ SAHGP 701_ LGDSA 706_ AAGPG 711_ PGGDA 716_ EYPTG 721_ KDTAK 726_ MGPPT 731_ARREQ
1: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress