Tripartite motif-containing protein 59 (RING finger protein 104) (Tumor suppressor TSBF-1)
1_MHNFE 6_ EELTC 11_ PICYS 16_ IFEDP 21_ RVLPC 26_ SHTFC 31_ RNCLE 36_ NILQA 41_ SGNFY 46_ IWRPL 51_ RIPLK 56_ CPNCR 61_ SITEI 66_ APTGI 71_ ESLPV 76_ NFALR 81_ AIIEK 86_ YQQED 91_ HPDIV 96_ TCPEH 101_ YRQPL 106_ NVYCL 111_ LDKKL 116_ VCGHC 121_ LTIGQ 126_ HHGHP 131_ IDDLQ 136_ SAYLK 141_ EKDTP 146_ QKLLE 151_ QLTDT 156_ HWTDL 161_ THLIE 166_ KLKEQ 171_ KSHSE 176_ KMIQG 181_ DKEAV 186_ LQYFK 191_ ELNDT 196_ LEQKK 201_ KSFLT 206_ ALCDV 211_ GNLIN 216_ QEYTP 221_ QIERM 226_ KEIRE 231_ QQLEL 236_ MALTI 241_ SLQEE 246_ SPLKF 251_ LEKVD 256_ DVRQH 261_ VQILK 266_ QRPLP 271_ EVQPV 276_ EIYPR 281_ VSKIL 286_ KEEWS 291_ RTEIG 296_ QIKNV 301_ LIPKM 306_ KISPK 311_ RMSCS 316_ WPGKD 321_ EKEVE 326_ FLKIL 331_ NIVVV 336_ TLISV 341_ ILMSI 346_ LFFNQ 351_ HIITF 356_ LSEIT 361_ LIWFS 366_ EASLS 371_ VYQSL 376_ SNSLH 381_ KVKNI 386_ LCHIF 391_ YLLKE 396_FVWKI
1: E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:30231667). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed:30231667). On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed:30231667). Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (By similarity)