Sodium channel subunit beta-4
1_MPGAG 6_ DGGKA 11_ PARWL 16_ GTGLL 21_ GLFLL 26_ PVTLS 31_ LEVSV 36_ GKATD 41_ IYAVN 46_ GTEIL 51_ LPCTF 56_ SSCFG 61_ FEDLH 66_ FRWTY 71_ NSSDA 76_ FKILI 81_ EGTVK 86_ NEKSD 91_ PKVTL 96_ KDDDR 101_ ITLVG 106_ STKEK 111_ MNNIS 116_ IVLRD 121_ LEFSD 126_ TGKYT 131_ CHVKN 136_ PKENN 141_ LQHHA 146_ TIFLQ 151_ VVDRL 156_ EEVDN 161_ TVTLI 166_ ILAVV 171_ GGVIG 176_ LLILI 181_ LLIKK 186_ LIIFI 191_ LKKTR 196_ EKKKE 201_ CLVSS 206_ SGNDN 211_ TENGL 216_ PGSKA 221_EEKPP
1: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:24297919). Modulates the activity of SCN1A/Nav1.1 (PubMed:33712547). Modulates the activity of SCN2A/Nav1.2 (PubMed:24297919)