Extracellular sulfatase Sulf-1 (hSulf-1) (EC 3.1.6.-)
1_MKYSC 6_ CALVL 11_ AVLGT 16_ ELLGS 21_ LCSTV 26_ RSPRF 31_ RGRIQ 36_ QERKN 41_ IRPNI 46_ ILVLT 51_ DDQDV 56_ ELGSL 61_ QVMNK 66_ TRKIM 71_ EHGGA 76_ TFINA 81_ FVTTP 86_ MCCPS 91_ RSSML 96_ TGKYV 101_ HNHNV 106_ YTNNE 111_ NCSSP 116_ SWQAM 121_ HEPRT 126_ FAVYL 131_ NNTGY 136_ RTAFF 141_ GKYLN 146_ EYNGS 151_ YIPPG 156_ WREWL 161_ GLIKN 166_ SRFYN 171_ YTVCR 176_ NGIKE 181_ KHGFD 186_ YAKDY 191_ FTDLI 196_ TNESI 201_ NYFKM 206_ SKRMY 211_ PHRPV 216_ MMVIS 221_ HAAPH 226_ GPEDS 231_ APQFS 236_ KLYPN 241_ ASQHI 246_ TPSYN 251_ YAPNM 256_ DKHWI 261_ MQYTG 266_ PMLPI 271_ HMEFT 276_ NILQR 281_ KRLQT 286_ LMSVD 291_ DSVER 296_ LYNML 301_ VETGE 306_ LENTY 311_ IIYTA 316_ DHGYH 321_ IGQFG 326_ LVKGK 331_ SMPYD 336_ FDIRV 341_ PFFIR 346_ GPSVE 351_ PGSIV 356_ PQIVL 361_ NIDLA 366_ PTILD 371_ IAGLD 376_ TPPDV 381_ DGKSV 386_ LKLLD 391_ PEKPG 396_ NRFRT 401_ NKKAK 406_ IWRDT 411_ FLVER 416_ GKFLR 421_ KKEES 426_ SKNIQ 431_ QSNHL 436_ PKYER 441_ VKELC 446_ QQARY 451_ QTACE 456_ QPGQK 461_ WQCIE 466_ DTSGK 471_ LRIHK 476_ CKGPS 481_ DLLTV 486_ RQSTR 491_ NLYAR 496_ GFHDK 501_ DKECS 506_ CRESG 511_ YRASR 516_ SQRKS 521_ QRQFL 526_ RNQGT 531_ PKYKP 536_ RFVHT 541_ RQTRS 546_ LSVEF 551_ EGEIY 556_ DINLE 561_ EEEEL 566_ QVLQP 571_ RNIAK 576_ RHDEG 581_ HKGPR 586_ DLQAS 591_ SGGNR 596_ GRMLA 601_ DSSNA 606_ VGPPT 611_ TVRVT 616_ HKCFI 621_ LPNDS 626_ IHCER 631_ ELYQS 636_ ARAWK 641_ DHKAY 646_ IDKEI 651_ EALQD 656_ KIKNL 661_ REVRG 666_ HLKRR 671_ KPEEC 676_ SCSKQ 681_ SYYNK 686_ EKGVK 691_ KQEKL 696_ KSHLH 701_ PFKEA 706_ AQEVD 711_ SKLQL 716_ FKENN 721_ RRRKK 726_ ERKEK 731_ RRQRK 736_ GEECS 741_ LPGLT 746_ CFTHD 751_ NNHWQ 756_ TAPFW 761_ NLGSF 766_ CACTS 771_ SNNNT 776_ YWCLR 781_ TVNET 786_ HNFLF 791_ CEFAT 796_ GFLEY 801_ FDMNT 806_ DPYQL 811_ TNTVH 816_ TVERG 821_ ILNQL 826_ HVQLM 831_ ELRSC 836_ QGYKQ 841_ CNPRP 846_ KNLDV 851_ GNKDG 856_ GSYDL 861_ HRGQL 866_WDGWE
1: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563)