E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)
1_MADEE 6_ AGGTE 11_ RMEIS 16_ AELPQ 21_ TPQRL 26_ ASWWD 31_ QQVDF 36_ YTAFL 41_ HHLAQ 46_ LVPEI 51_ YFAEM 56_ DPDLE 61_ KQEES 66_ VQMSI 71_ FTPLE 76_ WYLFG 81_ EDPDI 86_ CLEKL 91_ KHSGA 96_ FQLCG 101_ RVFKS 106_ GETTY 111_ SCRDC 116_ AIDPT 121_ CVLCM 126_ DCFQD 131_ SVHKN 136_ HRYKM 141_ HTSTG 146_ GGFCD 151_ CGDTE 156_ AWKTG 161_ PFCVN 166_ HEPGR 171_ AGTIK 176_ ENSRC 181_ PLNEE 186_ VIVQA 191_ RKIFP 196_ SVIKY 201_ VVEMT 206_ IWEEE 211_ KELPP 216_ ELQIR 221_ EKNER 226_ YYCVL 231_ FNDEH 236_ HSYDH 241_ VIYSL 246_ QRALD 251_ CELAE 256_ AQLHT 261_ TAIDK 266_ EGRRA 271_ VKAGA 276_ YAACQ 281_ EAKED 286_ IKSHS 291_ ENVSQ 296_ HPLHV 301_ EVLHS 306_ EIMAH 311_ QKFAL 316_ RLGSW 321_ MNKIM 326_ SYSSD 331_ FRQIF 336_ CQACL 341_ REEPD 346_ SENPC 351_ LISRL 356_ MLWDA 361_ KLYKG 366_ ARKIL 371_ HELIF 376_ SSFFM 381_ EMEYK 386_ KLFAM 391_ EFVKY 396_ YKQLQ 401_ KEYIS 406_ DDHDR 411_ SISIT 416_ ALSVQ 421_ MFTVP 426_ TLARH 431_ LIEEQ 436_ NVISV 441_ ITETL 446_ LEVLP 451_ EYLDR 456_ NNKFN 461_ FQGYS 466_ QDKLG 471_ RVYAV 476_ ICDLK 481_ YILIS 486_ KPTIW 491_ TERLR 496_ MQFLE 501_ GFRSF 506_ LKILT 511_ CMQGM 516_ EEIRR 521_ QVGQH 526_ IEVDP 531_ DWEAA 536_ IAIQM 541_ QLKNI 546_ LLMFQ 551_ EWCAC 556_ DEELL 561_ LVAYK 566_ ECHKA 571_ VMRCS 576_ TSFIS 581_ SSKTV 586_ VQSCG 591_ HSLET 596_ KSYRV 601_ SEDLV 606_ SIHLP 611_ LSRTL 616_ AGLHV 621_ RLSRL 626_ GAVSR 631_ LHEFV 636_ SFEDF 641_ QVEVL 646_ VEYPL 651_ RCLVL 656_ VAQVV 661_ AEMWR 666_ RNGLS 671_ LISQV 676_ FYYQD 681_ VKCRE 686_ EMYDK 691_ DIIML 696_ QIGAS 701_ LMDPN 706_ KFLLL 711_ VLQRY 716_ ELAEA 721_ FNKTI 726_ STKDQ 731_ DLIKQ 736_ YNTLI 741_ EEMLQ 746_ VLIYI 751_ VGERY 756_ VPGVG 761_ NVTKE 766_ EVTMR 771_ EIIHL 776_ LCIEP 781_ MPHSA 786_ IAKNL 791_ PENEN 796_ NETGL 801_ ENVIN 806_ KVATF 811_ KKPGV 816_ SGHGV 821_ YELKD 826_ ESLKD 831_ FNMYF 836_ YHYSK 841_ TQHSK 846_ AEHMQ 851_ KKRRK 856_ QENKD 861_ EALPP 866_ PPPPE 871_ FCPAF 876_ SKVIN 881_ LLNCD 886_ IMMYI 891_ LRTVF 896_ ERAID 901_ TDSNL 906_ WTEGM 911_ LQMAF 916_ HILAL 921_ GLLEE 926_ KQQLQ 931_ KAPEE 936_ EVTFD 941_ FYHKA 946_ SRLGS 951_ SAMNI 956_ QMLLE 961_ KLKGI 966_ PQLEG 971_ QKDMI 976_ TWILQ 981_ MFDTV 986_ KRLRE 991_ KSCLI 996_ VATTS 1001_ GSESI 1006_ KNDEI 1011_ THDKE 1016_ KAERK 1021_ RKAEA 1026_ ARLHR 1031_ QKIMA 1036_ QMSAL 1041_ QKNFI 1046_ ETHKL 1051_ MYDNT 1056_ SEMPG 1061_ KEDSI 1066_ MEEES 1071_ TPAVS 1076_ DYSRI 1081_ ALGPK 1086_ RGPSV 1091_ TEKEV 1096_ LTCIL 1101_ CQEEQ 1106_ EVKIE 1111_ NNAMV 1116_ LSACV 1121_ QKSTA 1126_ LTQHR 1131_ GKPIE 1136_ LSGEA 1141_ LDPLF 1146_ MDPDL 1151_ AYGTY 1156_ TGSCG 1161_ HVMHA 1166_ VCWQK 1171_ YFEAV 1176_ QLSSQ 1181_ QRIHV 1186_ DLFDL 1191_ ESGEY 1196_ LCPLC 1201_ KSLCN 1206_ TVIPI 1211_ IPLQP 1216_ QKINS 1221_ ENADA 1226_ LAQLL 1231_ TLARW 1236_ IQTVL 1241_ ARISG 1246_ YNIRH 1251_ AKGEN 1256_ PIPIF 1261_ FNQGM 1266_ GDSTL 1271_ EFHSI 1276_ LSFGV 1281_ ESSIK 1286_ YSNSI 1291_ KEMVI 1296_ LFATT 1301_ IYRIG 1306_ LKVPP 1311_ DERDP 1316_ RVPML 1321_ TWSTC 1326_ AFTIQ 1331_ AIENL 1336_ LGDEG 1341_ KPLFG 1346_ ALQNR 1351_ QHNGL 1356_ KALMQ 1361_ FAVAQ 1366_ RITCP 1371_ QVLIQ 1376_ KHLVR 1381_ LLSVV 1386_ LPNIK 1391_ SEDTP 1396_ CLLSI 1401_ DLFHV 1406_ LVGAV 1411_ LAFPS 1416_ LYWDD 1421_ PVDLQ 1426_ PSSVS 1431_ SSYNH 1436_ LYLFH 1441_ LITMA 1446_ HMLQI 1451_ LLTVD 1456_ TGLPL 1461_ AQVQE 1466_ DSEEA 1471_ HSASS 1476_ FFAEI 1481_ SQYTS 1486_ GSIGC 1491_ DIPGW 1496_ YLWVS 1501_ LKNGI 1506_ TPYLR 1511_ CAALF 1516_ FHYLL 1521_ GVTPP 1526_ EELHT 1531_ NSAEG 1536_ EYSAL 1541_ CSYLS 1546_ LPTNL 1551_ FLLFQ 1556_ EYWDT 1561_ VRPLL 1566_ QRWCA 1571_ DPALL 1576_ NCLKQ 1581_ KNTVV 1586_ RYPRK 1591_ RNSLI 1596_ ELPDD 1601_ YSCLL 1606_ NQASH 1611_ FRCPR 1616_ SADDE 1621_ RKHPV 1626_ LCLFC 1631_ GAILC 1636_ SQNIC 1641_ CQEIV 1646_ NGEEV 1651_ GACIF 1656_ HALHC 1661_ GAGVC 1666_ IFLKI 1671_ RECRV 1676_ VLVEG 1681_ KARGC 1686_ AYPAP 1691_ YLDEY 1696_ GETDP 1701_ GLKRG 1706_ NPLHL 1711_ SRERY 1716_ RKLHL 1721_ VWQQH 1726_ CIIEE 1731_ IARSQ 1736_ ETNQM 1741_LFGFN
1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:16311597, PubMed:18162545, PubMed:20835242, PubMed:28392261). Recognizes and binds proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:18162545, PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:18162545). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436)