E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)
1_MASEL 6_ EPEVQ 11_ AIDRS 16_ LLECS 21_ AEEIA 26_ GKWLQ 31_ ATDLT 36_ REVYQ 41_ HLAHY 46_ VPKIY 51_ CRGPN 56_ PFPQK 61_ EDMLA 66_ QHVLL 71_ GPMEW 76_ YLCGE 81_ DPAFG 86_ FPKLE 91_ QANKP 96_ SHLCG 101_ RVFKV 106_ GEPTY 111_ SCRDC 116_ AVDPT 121_ CVLCM 126_ ECFLG 131_ SIHRD 136_ HRYRM 141_ TTSGG 146_ GGFCD 151_ CGDTE 156_ AWKEG 161_ PYCQK 166_ HELNT 171_ SEIEE 176_ EEDPL 181_ VHLSE 186_ DVIAR 191_ TYNIF 196_ AITFR 201_ YAVEI 206_ LTWEK 211_ ESELP 216_ ADLEM 221_ VEKSD 226_ TYYCM 231_ LFNDE 236_ VHTYE 241_ QVIYT 246_ LQKAV 251_ NCTQK 256_ EAIGF 261_ ATTVD 266_ RDGRR 271_ SVRYG 276_ DFQYC 281_ EQAKS 286_ VIVRN 291_ TSRQT 296_ KPLKV 301_ QVMHS 306_ SIVAH 311_ QNFGL 316_ KLLSW 321_ LGSII 326_ GYSDG 331_ LRRIL 336_ CQVGL 341_ QEGPD 346_ GENSS 351_ LVDRL 356_ MLSDS 361_ KLWKG 366_ ARSVY 371_ HQLFM 376_ SSLLM 381_ DLKYK 386_ KLFAV 391_ RFAKN 396_ YQQLQ 401_ RDFME 406_ DDHER 411_ AVSVT 416_ ALSVQ 421_ FFTAP 426_ TLARM 431_ LITEE 436_ NLMSI 441_ IIKTF 446_ MDHLR 451_ HRDAQ 456_ GRFQF 461_ ERYTA 466_ LQAFK 471_ FRRVQ 476_ SLILD 481_ LKYVL 486_ ISKPT 491_ EWSDE 496_ LRQKF 501_ LEGFD 506_ AFLEL 511_ LKCMQ 516_ GMDPI 521_ TRQVG 526_ QHIEM 531_ EPEWE 536_ AAFTL 541_ QMKLT 546_ HVISM 551_ MQDWC 556_ ASDEK 561_ VLIEA 566_ YKKCL 571_ AVLMQ 576_ CHGGY 581_ TDGEQ 586_ PITLS 591_ ICGHS 596_ VETIR 601_ YCVSQ 606_ EKVSI 611_ HLPVS 616_ RLLAG 621_ LHVLL 626_ SKSEV 631_ AYKFP 636_ ELLPL 641_ SELSP 646_ PMLIE 651_ HPLRC 656_ LVLCA 661_ QVHAG 666_ MWRRN 671_ GFSLV 676_ NQIYY 681_ YHNVK 686_ CRREM 691_ FDKDV 696_ VMLQT 701_ GVSMM 706_ DPNHF 711_ LMIML 716_ SRFEL 721_ YQIFS 726_ TPDYG 731_ KRFSS 736_ EITHK 741_ DVVQQ 746_ NNTLI 751_ EEMLY 756_ LIIML 761_ VGERF 766_ SPGVG 771_ QVNAT 776_ DEIKR 781_ EIIHQ 786_ LSIKP 791_ MAHSE 796_ LVKSL 801_ PEDEN 806_ KETGM 811_ ESVIE 816_ AVAHF 821_ KKPGL 826_ TGRGM 831_ YELKP 836_ ECAKE 841_ FNLYF 846_ YHFSR 851_ AEQSK 856_ AEEAQ 861_ RKLKR 866_ QNRED 871_ TALPP 876_ PVLPP 881_ FCPLF 886_ ASLVN 891_ ILQSD 896_ VMLCI 901_ MGTIL 906_ QWAVE 911_ HNGYA 916_ WSESM 921_ LQRVL 926_ HLIGM 931_ ALQEE 936_ KQHLE 941_ NVTEE 946_ HVVTF 951_ TFTQK 956_ ISKPG 961_ EAPKN 966_ SPSIL 971_ AMLET 976_ LQNAP 981_ YLEVH 986_ KDMIR 991_ WILKT 996_ FNAVK 1001_ KMRES 1006_ SPTSP 1011_ VAETE 1016_ GTIME 1021_ ESSRD 1026_ KDKAE 1031_ RKRKA 1036_ EIARL 1041_ RREKI 1046_ MAQMS 1051_ EMQRH 1056_ FIDEN 1061_ KELFQ 1066_ QTLEL 1071_ DASTS 1076_ AVLDH 1081_ SPVAS 1086_ DMTLT 1091_ ALGPA 1096_ QTQVP 1101_ EQRQF 1106_ VTCIL 1111_ CQEEQ 1116_ EVKVE 1121_ SRAMV 1126_ LAAFV 1131_ QRSTV 1136_ LSKNR 1141_ SKFIQ 1146_ DPEKY 1151_ DPLFM 1156_ HPDLS 1161_ CGTHT 1166_ SSCGH 1171_ IMHAH 1176_ CWQRY 1181_ FDSVQ 1186_ AKEQR 1191_ RQQRL 1196_ RLHTS 1201_ YDVEN 1206_ GEFLC 1211_ PLCEC 1216_ LSNTV 1221_ IPLLL 1226_ PPRNI 1231_ FNNRL 1236_ NFSDQ 1241_ PNLTQ 1246_ WIRTI 1251_ SQQIK 1256_ ALQFL 1261_ RKEES 1266_ TPNNA 1271_ STKNS 1276_ ENVDE 1281_ LQLPE 1286_ GFRPD 1291_ FRPKI 1296_ PYSES 1301_ IKEML 1306_ TTFGT 1311_ ATYKV 1316_ GLKVH 1321_ PNEED 1326_ PRVPI 1331_ MCWGS 1336_ CAYTI 1341_ QSIER 1346_ ILSDE 1351_ DKPLF 1356_ GPLPC 1361_ RLDDC 1366_ LRSLT 1371_ RFAAA 1376_ HWTVA 1381_ SVSVV 1386_ QGHFC 1391_ KLFAS 1396_ LVPND 1401_ SHEEL 1406_ PCILD 1411_ IDMFH 1416_ LLVGL 1421_ VLAFP 1426_ ALQCQ 1431_ DFSGI 1436_ SLGTG 1441_ DLHIF 1446_ HLVTM 1451_ AHIIQ 1456_ ILLTS 1461_ CTEEN 1466_ GMDQE 1471_ NPPCE 1476_ EESAV 1481_ LALYK 1486_ TLHQY 1491_ TGSAL 1496_ KEIPS 1501_ GWHLW 1506_ RSVRA 1511_ GIMPF 1516_ LKCSA 1521_ LFFHY 1526_ LNGVP 1531_ SPPDI 1536_ QVPGT 1541_ SHFEH 1546_ LCSYL 1551_ SLPNN 1556_ LICLF 1561_ QENSE 1566_ IMNSL 1571_ IESWC 1576_ RNSEV 1581_ KRYLE 1586_ GERDA 1591_ IRYPR 1596_ ESNKL 1601_ INLPE 1606_ DYSSL 1611_ INQAS 1616_ NFSCP 1621_ KSGGD 1626_ KSRAP 1631_ TLCLV 1636_ CGSLL 1641_ CSQSY 1646_ CCQTE 1651_ LEGED 1656_ VGACT 1661_ AHTYS 1666_ CGSGV 1671_ GIFLR 1676_ VRECQ 1681_ VLFLA 1686_ GKTKG 1691_ CFYSP 1696_ PYLDD 1701_ YGETD 1706_ QGLRR 1711_ GNPLH 1716_ LCKER 1721_ FKKIQ 1726_ KLWHQ 1731_ HSVTE 1736_ EIGHA 1741_ QEANQ 1746_TLVGI
1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242, PubMed:28392261). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:20835242, PubMed:28392261). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:20835242, PubMed:28392261). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:20835242). In contrast, it strongly binds methylated N-degrons (PubMed:28392261). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (By similarity). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (PubMed:20298436). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis (By similarity). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (PubMed:38225265)