Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2)
1_MAELL 6_ RSLQD 11_ SQLVA 16_ RFQRR 21_ CGLFP 26_ APDEG 31_ PRENG 36_ ADPTE 41_ RAARV 46_ PGVEH 51_ LPAAN 56_ GKGGE 61_ APANG 66_ LRRAA 71_ APEAY 76_ VQKYV 81_ VKNYF 86_ YYYLF 91_ QFSAA 96_ LGQEV 101_ FYITF 106_ LPFTH 111_ WNIDP 116_ YLSRR 121_ LIIIW 126_ VLVMY 131_ IGQVA 136_ KDVLK 141_ WPRPS 146_ SPPVV 151_ KLEKR 156_ LIAEY 161_ GMPST 166_ HAMAA 171_ TAIAF 176_ TLLIS 181_ TMDRY 186_ QYPFV 191_ LGLVM 196_ AVVFS 201_ TLVCL 206_ SRLYT 211_ GMHTV 216_ LDVLG 221_ GVLIT 226_ ALLIV 231_ LTYPA 236_ WTFID 241_ CLDSA 246_ SPLFP 251_ VCVIV 256_ VPFFL 261_ CYNYP 266_ VSDYY 271_ SPTRA 276_ DTTTI 281_ LAAGA 286_ GVTIG 291_ FWINH 296_ FFQLV 301_ SKPAE 306_ SLPVI 311_ QNIPP 316_ LTTYM 321_ LVLGL 326_ TKFAV 331_ GIVLI 336_ LLVRQ 341_ LVQNL 346_ SLQVL 351_ YSWFK 356_ VVTRN 361_ KEARR 366_ RLEIE 371_ VPYKF 376_ VTYTS 381_ VGICA 386_ TTFVP 391_MLHRF
1: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity)