Gene name: TRIM48

Uniprot entry:

Q8IWZ4

Protein names:

E3 ubiquitin-protein ligase TRIM48 (EC 2.3.2.27) (RING finger protein 101) (Tripartite motif-containing protein 48)

Protein sequence:

1_MSRRI 6_ IVGTL 11_ QRTQR 16_ NMNSG 21_ ISQVF 26_ QRELT 31_ CPICM 36_ NYFID 41_ PVTID 46_ CGHSF 51_ CRPCF 56_ YLNWQ 61_ DIPIL 66_ TQCFE 71_ CIKTI 76_ QQRNL 81_ KTNIR 86_ LKKMA 91_ SLARK 96_ ASLWL 101_ FLSSE 106_ EQMCG 111_ IHRET 116_ KKMFC 121_ EVDRS 126_ LLCLL 131_ CSSSQ 136_ EHRYH 141_ RHCPA 146_ EWAAE 151_ EHWEK 156_ LLKKM 161_ QSLWE 166_ KACEN 171_ QRNLN 176_ VETTR 181_ ISHWK 186_ AFGDI 191_ LYRSE 196_ SVLLH 201_ MPQPL 206_ NLALR 211_ AGPIT 216_GLRDR

Protein annotations

Protein functions:

1: E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation (PubMed:29186683). This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress (PubMed:29186683). TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity (PubMed:29186683)