Bardet-Biedl syndrome 7 protein (BBS2-like protein 1)
1_MDLIL 6_ NRMDY 11_ LQVGV 16_ TSQKT 21_ MKLIP 26_ ASRHR 31_ ATQKV 36_ VIGDH 41_ DGVVM 46_ CFGMK 51_ KGEAA 56_ AVFKT 61_ LPGPK 66_ IARLE 71_ LGGVI 76_ NTPQE 81_ KIFIA 86_ AASEI 91_ RGFTK 96_ RGKQF 101_ LSFET 106_ NLTES 111_ IKAMH 116_ ISGSD 121_ LFLSA 126_ SYIYN 131_ HYCDC 136_ KDQHY 141_ YLSGD 146_ KINDV 151_ ICLPV 156_ ERLSR 161_ ITPVL 166_ ACQDR 171_ VLRVL 176_ QGSDV 181_ MYAVE 186_ VPGPP 191_ TVLAL 196_ HNGNG 201_ GDSGE 206_ DLLFG 211_ TSDGK 216_ LALIQ 221_ ITTSK 226_ PVRKW 231_ EIQNE 236_ KKRGG 241_ ILCID 246_ SFDIV 251_ GDGVK 256_ DLLVG 261_ RDDGM 266_ VEVYS 271_ FDNAN 276_ EPVLR 281_ FDQML 286_ SESVT 291_ SIQGG 296_ CVGKD 301_ SYDEI 306_ VVSTY 311_ SGWVT 316_ GLTTE 321_ PIHKE 326_ SGPGE 331_ ELKIN 336_ QEMQN 341_ KISSL 346_ RNELE 351_ HLQYK 356_ VLQER 361_ ENYQQ 366_ SSQSS 371_ KAKSA 376_ VPSFG 381_ INDKF 386_ TLNKD 391_ DASYS 396_ LILEV 401_ QTAID 406_ NVLIQ 411_ SDVPI 416_ DLLDV 421_ DKNSA 426_ VVSFS 431_ SCDSE 436_ SNDNF 441_ LLATY 446_ RCQAD 451_ TTRLE 456_ LKIRS 461_ IEGQY 466_ GTLQA 471_ YVTPR 476_ IQPKT 481_ CQVRQ 486_ YHIKP 491_ LSLHQ 496_ RTHFI 501_ DHDRP 506_ MNTLT 511_ LTGQF 516_ SFAEV 521_ HSWVV 526_ FCLPE 531_ VPEKP 536_ PAGEC 541_ VTFYF 546_ QNTFL 551_ DTQLE 556_ STYRK 561_ GEGVF 566_ KSDNI 571_ STISI 576_ LKDVL 581_ SKEAT 586_ KRKIN 591_ LNISY 596_ EINEV 601_ SVKHT 606_ LKLIH 611_ PKLEY 616_ QLLLA 621_ KKVQL 626_ IDALK 631_ ELQIH 636_ EGNTN 641_ FLIPE 646_ YHCIL 651_ EEADH 656_ LQEEY 661_ KKQPA 666_ HLERL 671_ YGMIT 676_ DLFID 681_ KFKFK 686_ GTNVK 691_ TKVPL 696_ LLEIL 701_ DSYDQ 706_NALIS
1: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization