SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)
1_MTRRC 6_ MPARP 11_ GFPSS 16_ PAPGS 21_ SPPRC 26_ HLRPG 31_ STAHA 36_ AAGKR 41_ TESPG 46_ DRKQS 51_ IIDFF 56_ KPASK 61_ QDRHM 66_ LDSPQ 71_ KSNIK 76_ YGGSR 81_ LSITG 86_ TEQFE 91_ RKLSS 96_ PKESK 101_ PKRVP 106_ PEKSP 111_ IIEAF 116_ MKGVK 121_ EHHED 126_ HGIHE 131_ SRRPC 136_ LSLAS 141_ KYLAK 146_ GTNIY 151_ VPSSY 156_ HLPKE 161_ MKSLK 166_ KKHRS 171_ PERRK 176_ SLFIH 181_ ENNEK 186_ NDRDR 191_ GKTNA 196_ DSKKQ 201_ TTVAE 206_ ADIFN 211_ NSSRS 216_ LSSRS 221_ SLSRH 226_ HPEES 231_ PLGAK 236_ FQLSL 241_ ASYCR 246_ ERELK 251_ RLRKE 256_ QMEQR 261_ INSEN 266_ SFSEA 271_ SSLSL 276_ KSSIE 281_ RKYKP 286_ RQEQR 291_ KQNDI 296_ IPGKN 301_ NLSNV 306_ ENGHL 311_ SRKRS 316_ SSDSW 321_ EPTSA 326_ GSKQN 331_ KFPEK 336_ RKRNS 341_ VDSDL 346_ KSTRE 351_ SMIPK 356_ ARESF 361_ LEKRP 366_ DGPHQ 371_ KEKFI 376_ KHIAL 381_ KTPGD 386_ VLRLE 391_ DISKE 396_ PSDET 401_ DGSSA 406_ GLAPS 411_ NSGNS 416_ GHHST 421_ RNSDQ 426_ IQVAG 431_ TKETK 436_ MQKPH 441_ LPLSQ 446_ EKSAI 451_ KKASN 456_ LQKNK 461_ TASST 466_ TKEKE 471_ TKLPL 476_ LSRVP 481_ SAGSS 486_ LVPLN 491_ AKNCA 496_ LPVSK 501_ KDKER 506_ SSSKE 511_ CSGHS 516_ TESTK 521_ HKEHK 526_ AKTNK 531_ ADSNV 536_ SSGKI 541_ SGGPL 546_ RSEYG 551_ TPTKS 556_ PPAAL 561_ EVVPC 566_ IPSPA 571_ APSDK 576_ APSEG 581_ ESSGN 586_ SNAGS 591_ SALKR 596_ KLRGD 601_ FDSDE 606_ ESLGY 611_ NLDSD 616_ EEEET 621_ LKSLE 626_ EIMAL 631_ NFNQT 636_ PAATG 641_ KPPAL 646_ SKGLR 651_ SQSSD 656_ YTGHV 661_ HPGTY 666_ TNTLE 671_ RLVKE 676_ MEDTQ 681_ RLDEL 686_ QKQLQ 691_ EDIRQ 696_ GRGIK 701_ SPIRI 706_ GEEDS 711_ TDDED 716_ GLLEE 721_ HKEFL 726_ KKFSV 731_ TIDAI 736_ PDHHP 741_ GEEIF 746_ NFLNS 751_ GKIFN 756_ QYTLD 761_ LRDSG 766_ FIGQS 771_ AVEKL 776_ ILKSG 781_ KTDQI 786_ FLTTQ 791_ GFLTS 796_ AYHYV 801_ QCPVP 806_ VLKWL 811_ FRMMS 816_ VHTDC 821_ IVSVQ 826_ ILSTL 831_ MEITI 836_ RNDTF 841_ SDSPV 846_ WPWIP 851_ SLSDV 856_ AAVFF 861_ NMGID 866_ FRSLF 871_ PLENL 876_ QPDFN 881_ EDYLV 886_ SETQT 891_ TSRGK 896_ ESEDS 901_ SYKPI 906_ FSTLP 911_ ETNIL 916_ NVVKF 921_ LGLCT 926_ SIHPE 931_ GYQDR 936_ EIMLL 941_ ILMLF 946_ KMSLE 951_ KQLKQ 956_ IPLVD 961_ FQSLL 966_ INLMK 971_ NIRDW 976_ NTKVP 981_ ELCLG 986_ INELS 991_ SHPHN 996_ LLWLV 1001_ QLVPN 1006_ WTSRG 1011_ RQLRQ 1016_ CLSLV 1021_ IISKL 1026_ LDEKH 1031_ EDVPN 1036_ ASNLQ 1041_ VSVLH 1046_ RYLVQ 1051_ MKPSD 1056_ LLKKM 1061_ VLKKK 1066_ AEQPD 1071_ GIIDD 1076_ SLHLE 1081_ LEKQA 1086_ YYLTY 1091_ ILLHL 1096_ VGEVS 1101_ CSHSF 1106_ SSGQR 1111_ KHFVL 1116_ LCGAL 1121_ EKHVK 1126_ CDIRE 1131_ DARLF 1136_ YRTKV 1141_ KDLVA 1146_ RIHGK 1151_ WQEII 1156_ QNCRP 1161_ TQGQL 1166_HDFWV
1: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674)