Signal peptide, CUB and EGF-like domain-containing protein 3
1_MGSGR 6_ VPGLC 11_ LLVLL 16_ VHARA 21_ AQYSK 26_ AAQDV 31_ DECVE 36_ GTDNC 41_ HIDAI 46_ CQNTP 51_ RSYKC 56_ ICKSG 61_ YTGDG 66_ KHCKD 71_ VDECE 76_ REDNA 81_ GCVHD 86_ CVNIP 91_ GNYRC 96_ TCYDG 101_ FHLAH 106_ DGHNC 111_ LDVDE 116_ CAEGN 121_ GGCQQ 126_ SCVNM 131_ MGSYE 136_ CHCRE 141_ GFFLS 146_ DNQHT 151_ CIQRP 156_ EEGMN 161_ CMNKN 166_ HGCAH 171_ ICRET 176_ PKGGI 181_ ACECR 186_ PGFEL 191_ TKNQR 196_ DCKLT 201_ CNYGN 206_ GGCQH 211_ TCDDT 216_ EQGPR 221_ CGCHI 226_ KFVLH 231_ TDGKT 236_ CIETC 241_ AVNNG 246_ GCDSK 251_ CHDAA 256_ TGVHC 261_ TCPVG 266_ FMLQP 271_ DRKTC 276_ KDIDE 281_ CRLNN 286_ GGCDH 291_ ICRNT 296_ VGSFE 301_ CSCKK 306_ GYKLL 311_ INERN 316_ CQDID 321_ ECSFD 326_ RTCDH 331_ ICVNT 336_ PGSFQ 341_ CLCHR 346_ GYLLY 351_ GITHC 356_ GDVDE 361_ CSINR 366_ GGCRF 371_ GCINT 376_ PGSYQ 381_ CTCPA 386_ GQGRL 391_ HWNGK 396_ DCTEP 401_ LKCQG 406_ SPGAS 411_ KAMLS 416_ CNRSG 421_ KKDTC 426_ ALTCP 431_ SRARF 436_ LPESE 441_ NGFTV 446_ SCGTP 451_ SPRAA 456_ PARAG 461_ HNGNS 466_ TNSNH 471_ CHEAA 476_ VLSIK 481_ QRASF 486_ KIKDA 491_ KCRLH 496_ LRNKG 501_ KTEEA 506_ GRITG 511_ PGGAP 516_ CSECQ 521_ VTFIH 526_ LKCDS 531_ SRKGK 536_ GRRAR 541_ TPPGK 546_ EVTRL 551_ TLELE 556_ AEVRA 561_ EETTA 566_ SCGLP 571_ CLRQR 576_ MERRL 581_ KGSLK 586_ MLRKS 591_ INQDR 596_ FLLRL 601_ AGLDY 606_ ELAHK 611_ PGLVA 616_ GERAE 621_ PMESC 626_ RPGQH 631_ RAGTK 636_ CVSCP 641_ QGTYY 646_ HGQTE 651_ QCVPC 656_ PAGTF 661_ QEREG 666_ QLSCD 671_ LCPGS 676_ DAHGP 681_ LGATN 686_ VTTCA 691_ GQCPP 696_ GQHSV 701_ DGFKP 706_ CQPCP 711_ RGTYQ 716_ PEAGR 721_ TLCFP 726_ CGGGL 731_ TTKHE 736_ GAISF 741_ QDCDT 746_ KVQCS 751_ PGHYY 756_ NTSIH 761_ RCIRC 766_ AMGSY 771_ QPDFR 776_ QNFCS 781_ RCPGN 786_ TSTDF 791_ DGSTS 796_ VAQCK 801_ NRQCG 806_ GELGE 811_ FTGYI 816_ ESPNY 821_ PGNYP 826_ AGVEC 831_ IWNIN 836_ PPPKR 841_ KILIV 846_ VPEIF 851_ LPSED 856_ ECGDV 861_ LVMRK 866_ NSSPS 871_ SITTY 876_ ETCQT 881_ YERPI 886_ AFTAR 891_ SRKLW 896_ INFKT 901_ SEANS 906_ ARGFQ 911_ IPYVT 916_ YDEDY 921_ EQLVE 926_ DIVRD 931_ GRLYA 936_ SENHQ 941_ EILKD 946_ KKLIK 951_ AFFEV 956_ LAHPQ 961_ NYFKY 966_ TEKHK 971_ EMLPK 976_ SFIKL 981_ LRSKV 986_SSFLR
1: Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (PubMed:33308444). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression