Spindle and kinetochore-associated protein 3
1_MDPIR 6_ SFCGK 11_ LRSLA 16_ STLDC 21_ ETARL 26_ QRALD 31_ GEESD 36_ FEDYP 41_ MRILY 46_ DLHSE 51_ VQTLK 56_ DDVNI 61_ LLDKA 66_ RLENQ 71_ EGIDF 76_ IKATK 81_ VLMEK 86_ NSMDI 91_ MKIRE 96_ YFQKY 101_ GYSPR 106_ VKKNS 111_ VHEQE 116_ AINSD 121_ PELSN 126_ CENFQ 131_ KTDVK 136_ DDLSD 141_ PPVAS 146_ SCISE 151_ KSPRS 156_ PQLSD 161_ FGLER 166_ YIVSQ 171_ VLPNP 176_ PQAVN 181_ NYKEE 186_ PVIVT 191_ PPTKQ 196_ SLVKV 201_ LKTPK 206_ CALKM 211_ DDFEC 216_ VTPKL 221_ EHFGI 226_ SEYTM 231_ CLNED 236_ YTMGL 241_ KNARN 246_ NKSEE 251_ AIDTE 256_ SRLND 261_ NVFAT 266_ PSPII 271_ QQLEK 276_ SDAEY 281_ TNSPL 286_ VPTFC 291_ TPGLK 296_ IPSTK 301_ NSIAL 306_ VSTNY 311_ PLSKT 316_ NSSSN 321_ DLEVE 326_ DRTSL 331_ VLNSD 336_ TCFEN 341_ LTDPS 346_ SPTIS 351_ SYENL 356_ LRTPT 361_ PPEVT 366_ KIPED 371_ ILQLL 376_ SKYNS 381_ NLATP 386_ IAIKA 391_ VPPSK 396_ RFLKH 401_ GQNIR 406_DVSNK
1: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020)