DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)
1_MGVWL 6_ NKDDY 11_ IRDLK 16_ RIILC 21_ FLIVY 26_ MAILV 31_ GTDQD 36_ FYSLL 41_ GVSKT 46_ ASSRE 51_ IRQAF 56_ KKLAL 61_ KLHPD 66_ KNPNN 71_ PNAHG 76_ DFLKI 81_ NRAYE 86_ VLKDE 91_ DLRKK 96_ YDKYG 101_ EKGLE 106_ DNQGG 111_ QYESW 116_ NYYRY 121_ DFGIY 126_ DDDPE 131_ IITLE 136_ RREFD 141_ AAVNS 146_ GELWF 151_ VNFYS 156_ PGCSH 161_ CHDLA 166_ PTWRD 171_ FAKEV 176_ DGLLR 181_ IGAVN 186_ CGDDR 191_ MLCRM 196_ KGVNS 201_ YPSLF 206_ IFRSG 211_ MAPVK 216_ YHGDR 221_ SKESL 226_ VSFAM 231_ QHVRS 236_ TVTEL 241_ WTGNF 246_ VNSIQ 251_ TAFAA 256_ GIGWL 261_ ITFCS 266_ KGGDC 271_ LTSQT 276_ RLRLS 281_ GMLDG 286_ LVNVG 291_ WMDCA 296_ TQDNL 301_ CKSLD 306_ ITTST 311_ TAYFP 316_ PGATL 321_ NNKEK 326_ NSILF 331_ LNSLD 336_ AKEIY 341_ LEVIH 346_ NLPDF 351_ ELLSA 356_ NTLED 361_ RLAHH 366_ RWLLF 371_ FHFGK 376_ NENSN 381_ DPELK 386_ KLKTL 391_ LKNDH 396_ IQVGR 401_ FDCSS 406_ APDIC 411_ SNLYV 416_ FQPSL 421_ AVFKG 426_ QGTKE 431_ YEIHH 436_ GKKIL 441_ YDILA 446_ FAKES 451_ VNSHV 456_ TTLGP 461_ QNFPA 466_ NDKEP 471_ WLVDF 476_ FAPWC 481_ PPCRA 486_ LLPEL 491_ RRASN 496_ LLYGQ 501_ LKFGT 506_ LDCTV 511_ HEGLC 516_ NMYNI 521_ QAYPT 526_ TVVFN 531_ QSNIH 536_ EYEGH 541_ HSAEQ 546_ ILEFI 551_ EDLMN 556_ PSVVS 561_ LTPTT 566_ FNELV 571_ TQRKH 576_ NEVWM 581_ VDFYS 586_ PWCHP 591_ CQVLM 596_ PEWKR 601_ MARTL 606_ TGLIN 611_ VGSID 616_ CQQYH 621_ SFCAQ 626_ ENVQR 631_ YPEIR 636_ FFPPK 641_ SNKAY 646_ HYHSY 651_ NGWNR 656_ DAYSL 661_ RIWGL 666_ GFLPQ 671_ VSTDL 676_ TPQTF 681_ SEKVL 686_ QGKNH 691_ WVIDF 696_ YAPWC 701_ GPCQN 706_ FAPEF 711_ ELLAR 716_ MIKGK 721_ VKAGK 726_ VDCQA 731_ YAQTC 736_ QKAGI 741_ RAYPT 746_ VKFYF 751_ YERAK 756_ RNFQE 761_ EQINT 766_ RDAKA 771_ IAALI 776_ SEKLE 781_ TLRNQ 786_GKRNK
1: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress