Tumor protein p53-inducible nuclear protein 2 (Diabetes and obesity-regulated gene) (p53-inducible protein U) (PIG-U)
1_MFQRL 6_ SSLFF 11_ STPSP 16_ PEDPD 21_ CPRAF 26_ VSEED 31_ EVDGW 36_ LIIDL 41_ PDSYA 46_ APPSP 51_ GAAPA 56_ PAGRP 61_ PPAPS 66_ LMDES 71_ WFVTP 76_ PACFT 81_ AEGPG 86_ LGPAR 91_ LQSSP 96_ LEDLL 101_ IEHPS 106_ MSVYV 111_ TGSTI 116_ VLEPG 121_ SPSPL 126_ PDAAL 131_ PDGDL 136_ SEGEL 141_ TPARR 146_ EPRAA 151_ RHAAP 156_ LPARA 161_ ALLEK 166_ AGQVR 171_ RLQRA 176_ RQRAE 181_ RHALS 186_ AKAVQ 191_ RQNRA 196_ RESRP 201_ RRSKN 206_ QSSFI 211_YQPCQ
1: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA