Negative elongation factor C/D (NELF-C/D) (TH1-like protein)
1_MAGAV 6_ PGAIM 11_ DEDYY 16_ GSAAE 21_ WGDEA 26_ DGGQQ 31_ EDDSG 36_ EGEDD 41_ AEVQQ 46_ ECLHK 51_ FSTRD 56_ YIMEP 61_ SIFNT 66_ LKRYF 71_ QAGGS 76_ PENVI 81_ QLLSE 86_ NYTAV 91_ AQTVN 96_ LLAEW 101_ LIQTG 106_ VEPVQ 111_ VQETV 116_ ENHLK 121_ SLLIK 126_ HFDPR 131_ KADSI 136_ FTEEG 141_ ETPAW 146_ LEQMI 151_ AHTTW 156_ RDLFY 161_ KLAEA 166_ HPDCL 171_ MLNFT 176_ VKLIS 181_ DAGYQ 186_ GEITS 191_ VSTAC 196_ QQLEV 201_ FSRVL 206_ RTSLA 211_ TILDG 216_ GEENL 221_ EKNLP 226_ EFAKM 231_ VCHGE 236_ HTYLF 241_ AQAMM 246_ SVLAQ 251_ EEQGG 256_ SAVRR 261_ IAQEV 266_ QRFAQ 271_ EKGHD 276_ ASQIT 281_ LALGT 286_ AASYP 291_ RACQA 296_ LGAML 301_ SKGAL 306_ NPADI 311_ TVLFK 316_ MFTSM 321_ DPPPV 326_ ELIRV 331_ PAFLD 336_ LFMQS 341_ LFKPG 346_ ARINQ 351_ DHKHK 356_ YIHIL 361_ AYAAS 366_ VVETW 371_ KKNKR 376_ VSINK 381_ DELKS 386_ TSKAV 391_ ETVHN 396_ LCCNE 401_ NKGAS 406_ ELVAE 411_ LSTLY 416_ QCIRF 421_ PVVAM 426_ GVLKW 431_ VDWTV 436_ SEPRY 441_ FQLQT 446_ DHTPV 451_ HLALL 456_ DEIST 461_ CHQLL 466_ HPQVL 471_ QLLVK 476_ LFETE 481_ HSQLD 486_ VMEQL 491_ ELKKT 496_ LLDRM 501_ VHLLS 506_ RGYVL 511_ PVVSY 516_ IRKCL 521_ EKLDT 526_ DISLI 531_ RYFVT 536_ EVLDV 541_ IAPPY 546_ TSDFV 551_ QLFLP 556_ ILEND 561_ SIAGT 566_ IKTEG 571_ EHDPV 576_ TEFIA 581_HCKSN
1: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401)
2: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II