Polycomb group protein ASXL1 (Additional sex combs-like protein 1)
1_MKDKQ 6_ KKKKE 11_ RTWAE 16_ AARLV 21_ LENYS 26_ DAPMT 31_ PKQIL 36_ QVIEA 41_ EGLKE 46_ MRSGT 51_ SPLAC 56_ LNAML 61_ HSNSR 66_ GGEGL 71_ FYKLP 76_ GRISL 81_ FTLKK 86_ DALQW 91_ SRHPA 96_ TVEGE 101_ EPEDT 106_ ADVES 111_ CGSNE 116_ ASTVS 121_ GENDV 126_ SLDET 131_ SSNAS 136_ CSTES 141_ QSRPL 146_ SNPRD 151_ SYRAS 156_ SQANK 161_ QKKKT 166_ GVMLP 171_ RVVLT 176_ PLKVN 181_ GAHVE 186_ SASGF 191_ SGCHA 196_ DGESG 201_ SPSSS 206_ SSGSL 211_ ALGSA 216_ AIRGQ 221_ AEVTQ 226_ DPAPL 231_ LRGFR 236_ KPATG 241_ QMKRN 246_ RGEEI 251_ DFETP 256_ GSILV 261_ NTNLR 266_ ALINS 271_ RTFHA 276_ LPSHF 281_ QQQLL 286_ FLLPE 291_ VDRQV 296_ GTDGL 301_ LRLSS 306_ SALNN 311_ EFFTH 316_ AAQSW 321_ RERLA 326_ DGEFT 331_ HEMQV 336_ RIRQE 341_ MEKEK 346_ KVEQW 351_ KEKFF 356_ EDYYG 361_ QKLGL 366_ TKEES 371_ LQQNV 376_ GQEEA 381_ EIKSG 386_ LCVPG 391_ ESVRI 396_ QRGPA 401_ TRQRD 406_ GHFKK 411_ RSRPD 416_ LRTRA 421_ RRNLY 426_ KKQES 431_ EQAGV 436_ AKDAK 441_ SVASD 446_ VPLYK 451_ DGEAK 456_ TDPAG 461_ LSSPH 466_ LPGTS 471_ SAAPD 476_ LEGPE 481_ FPVES 486_ VASRI 491_ QAEPD 496_ NLARA 501_ SASPD 506_ RIPSL 511_ PQETV 516_ DQEPK 521_ DQKRK 526_ SFEQA 531_ ASASF 536_ PEKKP 541_ RLEDR 546_ QSFRN 551_ TIESV 556_ HTEKP 561_ QPTKE 566_ EPKVP 571_ PIRIQ 576_ LSRIK 581_ PPWVV 586_ KGQPT 591_ YQICP 596_ RIIPT 601_ TESSC 606_ RGWTG 611_ ARTLA 616_ DIKAR 621_ ALQVR 626_ GARGH 631_ HCHRE 636_ AATTA 641_ IGGGG 646_ GPGGG 651_ GGGAT 656_ DEGGG 661_ RGSSS 666_ GDGGE 671_ ACGHP 676_ EPRGG 681_ PSTPG 686_ KCTSD 691_ LQRTQ 696_ LLPPY 701_ PLNGE 706_ HTQAG 711_ TAMSR 716_ ARRED 721_ LPSLR 726_ KEESC 731_ LLQRA 736_ TVGLT 741_ DGLGD 746_ ASQLP 751_ VAPTG 756_ DQPCQ 761_ ALPLL 766_ SSQTS 771_ VAERL 776_ VEQPQ 781_ LHPDV 786_ RTECE 791_ SGTTS 796_ WESDD 801_ EEQGP 806_ TVPAD 811_ NGPIP 816_ SLVGD 821_ DTLEK 826_ GTGQA 831_ LDSHP 836_ TMKDP 841_ VNVTP 846_ SSTPE 851_ SSPTD 856_ CLQNR 861_ AFDDE 866_ LGLGG 871_ SCPPM 876_ RESDT 881_ RQENL 886_ KTKAL 891_ VSNSS 896_ LHWIP 901_ IPSND 906_ EVVKQ 911_ PKPES 916_ REHIP 921_ SVEPQ 926_ VGEEW 931_ EKAAP 936_ TPPAL 941_ PGDLT 946_ AEEGL 951_ DPLDS 956_ LTSLW 961_ TVPSR 966_ GGSDS 971_ NGSYC 976_ QQVDI 981_ EKLKI 986_ NGDSE 991_ ALSPH 996_ GESTD 1001_ TASDF 1006_ EGHLT 1011_ EDSSE 1016_ ADTRE 1021_ AAVTK 1026_ GSSVD 1031_ KDEKP 1036_ NWNQS 1041_ APLSK 1046_ VNGDM 1051_ RLVTR 1056_ TDGMV 1061_ APQSW 1066_ VSRVC 1071_ AVRQK 1076_ IPDSL 1081_ LLAST 1086_ EYQPR 1091_ AVCLS 1096_ MPGSS 1101_ VEATN 1106_ PLVMQ 1111_ LLQGS 1116_ LPLEK 1121_ VLPPA 1126_ HDDSM 1131_ SESPQ 1136_ VPLTK 1141_ DQSHG 1146_ SLRMG 1151_ SLHGL 1156_ GKNSG 1161_ MVDGS 1166_ SPSSL 1171_ RALKE 1176_ PLLPD 1181_ SCETG 1186_ TGLAR 1191_ IEATQ 1196_ APGAP 1201_ QKNCK 1206_ AVPSF 1211_ DSLHP 1216_ VTNPI 1221_ TSSRK 1226_ LEEMD 1231_ SKEQF 1236_ SSFSC 1241_ EDQKE 1246_ VRAMS 1251_ QDSNS 1256_ NAAPG 1261_ KSPGD 1266_ LTTSR 1271_ TPRFS 1276_ SPNVI 1281_ SFGPE 1286_ QTGRA 1291_ LGDQS 1296_ NVTGQ 1301_ GKKLF 1306_ GSGNV 1311_ AATLQ 1316_ RPRPA 1321_ DPMPL 1326_ PAEIP 1331_ PVFPS 1336_ GKLGP 1341_ STNSM 1346_ SGGVQ 1351_ TPRED 1356_ WAPKP 1361_ HAFVG 1366_ SVKNE 1371_ KTFVG 1376_ GPLKA 1381_ NAENR 1386_ KATGH 1391_ SPLEL 1396_ VGHLE 1401_ GMPFV 1406_ MDLPF 1411_ WKLPR 1416_ EPGKG 1421_ LSEPL 1426_ EPSSL 1431_ PSQLS 1436_ IKQAF 1441_ YGKLS 1446_ KLQLS 1451_ STSFN 1456_ YSSSS 1461_ PTFPK 1466_ GLAGS 1471_ VVQLS 1476_ HKANF 1481_ GASHS 1486_ ASLSL 1491_ QMFTD 1496_ SSTVE 1501_ SISLQ 1506_ CACSL 1511_ KAMIM 1516_ CQGCG 1521_ AFCHD 1526_ DCIGP 1531_ SKLCV 1536_LCLVV
1: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as a coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:30664650, PubMed:36180891). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650). Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818)