Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)
1_MWGRT 6_ ARRRC 11_ PRELR 16_ RGREA 21_ LLVLL 26_ ALLAL 31_ AGLGS 36_ VLRAQ 41_ RGAGA 46_ GAAEP 51_ GPPRT 56_ PRPGR 61_ REPVM 66_ PRPPV 71_ PANAL 76_ GARGE 81_ AVRLQ 86_ LQGEE 91_ LRLQE 96_ ESVRL 101_ HQINI 106_ YLSDR 111_ ISLHR 116_ RLPER 121_ WNPLC 126_ KEKKY 131_ DYDNL 136_ PRTSV 141_ IIAFY 146_ NEAWS 151_ TLLRT 156_ VYSVL 161_ ETSPD 166_ ILLEE 171_ VILVD 176_ DYSDR 181_ EHLKE 186_ RLANE 191_ LSGLP 196_ KVRLI 201_ RANKR 206_ EGLVR 211_ ARLLG 216_ ASAAR 221_ GDVLT 226_ FLDCH 231_ CECHE 236_ GWLEP 241_ LLQRI 246_ HEEES 251_ AVVCP 256_ VIDVI 261_ DWNTF 266_ EYLGN 271_ SGEPQ 276_ IGGFD 281_ WRLVF 286_ TWHTV 291_ PERER 296_ IRMQS 301_ PVDVI 306_ RSPTM 311_ AGGLF 316_ AVSKK 321_ YFEYL 326_ GSYDT 331_ GMEVW 336_ GGENL 341_ EFSFR 346_ IWQCG 351_ GVLET 356_ HPCSH 361_ VGHVF 366_ PKQAP 371_ YSRNK 376_ ALANS 381_ VRAAE 386_ VWMDE 391_ FKELY 396_ YHRNP 401_ RARLE 406_ PFGDV 411_ TERKQ 416_ LRDKL 421_ QCKDF 426_ KWFLE 431_ TVYPE 436_ LHVPE 441_ DRPGF 446_ FGMLQ 451_ NKGLT 456_ DYCFD 461_ YNPPD 466_ ENQIV 471_ GHQVI 476_ LYLCH 481_ GMGQN 486_ QFFEY 491_ TSQKE 496_ IRYNT 501_ HQPEG 506_ CIAVE 511_ AGMDT 516_ LIMHL 521_ CEETA 526_ PENQK 531_ FILQE 536_ DGSLF 541_ HEQSK 546_ KCVQA 551_ ARKES 556_ SDSFV 561_ PLLRD 566_ CTNSD 571_ HQKWF 576_FKERM
1: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs