Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)
1_MDFSM 6_ VAGAA 11_ AYNEK 16_ SGRIT 21_ SLSLL 26_ FQKVF 31_ AQIFP 36_ QWRKG 41_ NTEEC 46_ LPYKC 51_ SETGA 56_ LGENY 61_ SWQIP 66_ INHND 71_ FKILK 76_ NNERQ 81_ LCEVL 86_ QNKFG 91_ CISTL 96_ VSPVQ 101_ EGNSK 106_ SLQVF 111_ RKMLT 116_ PRIEL 121_ SVWKD 126_ DLTTH 131_ AVDAV 136_ VNAAN 141_ EDLLH 146_ GGGLA 151_ LALVK 156_ AGGFE 161_ IQEES 166_ KQFVA 171_ RYGKV 176_ SAGEI 181_ AVTGA 186_ GRLPC 191_ KQIIH 196_ AVGPR 201_ WMEWD 206_ KQGCT 211_ GKLQR 216_ AIVSI 221_ LNYVI 226_ YKNTH 231_ IKTVA 236_ IPALS 241_ SGIFQ 246_ FPLNL 251_ CTKTI 256_ VETIR 261_ VSLQG 266_ KPMMS 271_ NLKEI 276_ HLVSN 281_ EDPTV 286_ AAFKA 291_ ASEFI 296_ LGKSE 301_ LGQET 306_ TPSFN 311_ AMVVN 316_ NLTLQ 321_ IVQGH 326_ IEWQT 331_ ADVIV 336_ NSVNP 341_ HDITV 346_ GPVAK 351_ SILQQ 356_ AGVEM 361_ KSEFL 366_ ATKAK 371_ QFQRS 376_ QLVLV 381_ TKGFN 386_ LFCKY 391_ IYHVL 396_ WHSEF 401_ PKPQI 406_ LKHAM 411_ KECLE 416_ KCIEQ 421_ NITSI 426_ SFPAL 431_ GTGNM 436_ EIKKE 441_ TAAEI 446_ LFDEV 451_ LTFAK 456_ DHVKH 461_ QLTVK 466_ FVIFP 471_ TDLEI 476_ YKAFS 481_ SEMAK 486_ RSKML 491_ SLNNY 496_ SVPQS 501_ TREEK 506_ RENGL 511_ EARSP 516_ AINLM 521_ GFNVE 526_ EMYEA 531_ HAWIQ 536_ RILSL 541_ QNHHI 546_ IENNH 551_ ILYLG 556_ RKEHD 561_ ILSQL 566_ QKTSS 571_ VSITE 576_ IISPG 581_ RTELE 586_ IEGAR 591_ ADLIE 596_ VVMNI 601_ EDMLC 606_ KVQEE 611_ MARKK 616_ ERGLW 621_ RSLGQ 626_ WTIQQ 631_ QKTQD 636_ EMKEN 641_ IIFLK 646_ CPVPP 651_ TQELL 656_ DQKKQ 661_ FEKCG 666_ LQVLK 671_ VEKID 676_ NEVLM 681_ AAFQR 686_ KKKMM 691_ EEKLH 696_ RQPVS 701_ HRLFQ 706_ QVPYQ 711_ FCNVV 716_ CRVGF 721_ QRMYS 726_ TPCDP 731_ KYGAG 736_ IYFTK 741_ NLKNL 746_ AEKAK 751_ KISAA 756_ DKLIY 761_ VFEAE 766_ VLTGF 771_ FCQGH 776_ PLNIV 781_ PPPLS 786_ PGAID 791_ GHDSV 796_ VDNVS 801_ SPETF 806_ VIFSG 811_ MQAIP 816_ QYLWT 821_ CTQEY 826_ VQSQD 831_ YSSGP 836_ MRPFA 841_ QHPWR 846_GFASG
1: ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300)