Kelch domain-containing protein 8B
1_MSAGG 6_ GRAFA 11_ WQVFP 16_ PMPTC 21_ RVYGT 26_ VAHQD 31_ GHLLV 36_ LGGCG 41_ RAGLP 46_ LDTAE 51_ TLDMA 56_ SHTWL 61_ ALAPL 66_ PTARA 71_ GAAAV 76_ VLGKQ 81_ VLVVG 86_ GVDEV 91_ QSPVA 96_ AVEAF 101_ LMDEG 106_ RWERR 111_ ATLPQ 116_ AAMGV 121_ ATVER 126_ DGMVY 131_ ALGGM 136_ GPDTA 141_ PQAQV 146_ RVYEP 151_ RRDCW 156_ LSLPS 161_ MPTPC 166_ YGAST 171_ FLHGN 176_ KIYVL 181_ GGRQG 186_ KLPVT 191_ AFEAF 196_ DLEAR 201_ TWTRH 206_ PSLPS 211_ RRAFA 216_ GCAMA 221_ EGSVF 226_ SLGGL 231_ QQPGP 236_ HNFYS 241_ RPHFV 246_ NTVEM 251_ FDLEH 256_ GSWTK 261_ LPRSL 266_ RMRDK 271_ RADFV 276_ VGSLG 281_ GHIVA 286_ IGGLG 291_ NQPCP 296_ LGSVE 301_ SFSLA 306_ RRRWE 311_ ALPAM 316_ PTARC 321_ SCSSL 326_ QAGPR 331_ LFVIG 336_ GVAQG 341_ PSQAV 346_EALCL
1: Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010)