Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2)
1_MADFA 6_ GPSSA 11_ GRKAG 16_ APRCS 21_ RKAAG 26_ TKQTS 31_ TLKQE 36_ DASKR 41_ KAELE 46_ AAVRK 51_ KIEFE 56_ RKALH 61_ IVEQL 66_ LEENI 71_ TEEFL 76_ MECGR 81_ FITPA 86_ HYSDV 91_ VDERS 96_ IVKLC 101_ GYPLC 106_ QKKLG 111_ IVPKQ 116_ KYKIS 121_ TKTNK 126_ VYDIT 131_ ERKSF 136_ CSNFC 141_ YQASK 146_ FFEAQ 151_ IPKTP 156_ VWVRE 161_ EERHP 166_ DFQLL 171_ KEEQS 176_ GHSGE 181_ EVQLC 186_ SKAIK 191_ TSDID 196_ NPSHF 201_ EKQYE 206_ SSSSS 211_ THSDS 216_ SSDNE 221_ QDFVS 226_ SILPG 231_ NRPNS 236_ TNIRP 241_ QLHQK 246_ SIMKK 251_ KAGHK 256_ ANSKH 261_ KDKEQ 266_ TVVDV 271_ TEQLG 276_ DCKLD 281_ SQEKD 286_ ATCEL 291_ PLQKV 296_ NTQSS 301_ SNSTL 306_ PERLK 311_ ASENS 316_ ESEYS 321_ RSEIT 326_ LVGIS 331_ KKSAE 336_ HFKRK 341_ FAKSN 346_ QVSRS 351_ VSSSV 356_ QVCPE 361_ VGKRN 366_ LLKVL 371_ KETLI 376_ EWKTE 381_ ETLRF 386_ LYGQN 391_ YASVC 396_ LKPEA 401_ SLVKE 406_ ELDED 411_ DIISD 416_ PDSHF 421_ PAWRE 426_ SQNSL 431_ DESLP 436_ FRGSG 441_ TAIKP 446_ LPSYE 451_ NLKKE 456_ TEKLN 461_ LRIRE 466_ FYRGR 471_ YVLGE 476_ ETTKS 481_ QDSEE 486_ HDSTF 491_ PLIDS 496_ SSQNQ 501_ IRKRI 506_ VLEKL 511_ SKVLP 516_ GLLVP 521_ LQITL 526_ GDIYT 531_ QLKNL 536_ VRTFR 541_ LTNRN 546_ IIHKP 551_ AEWTL 556_ IAMVL 561_ LSLLT 566_ PILGI 571_ QKHSQ 576_ EGMVF 581_ TRFLD 586_ TLLEE 591_ LHLKN 596_ EDLES 601_ LTIIF 606_RTSCL
1: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (PubMed:17643375, PubMed:22137580, PubMed:24997600). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (PubMed:30118681)