Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
1_MATPS 6_ KKTST 11_ PSPQP 16_ SKRAL 21_ PRDPS 26_ SEVPS 31_ KRKNS 36_ APQLP 41_ LLQSS 46_ GPFVE 51_ GSIVR 56_ ISMEN 61_ FLTYD 66_ ICEVS 71_ PGPHL 76_ NMIVG 81_ ANGTG 86_ KSSIV 91_ CAICL 96_ GLAGK 101_ PAFMG 106_ RADKV 111_ GFFVK 116_ RGCSR 121_ GMVEI 126_ ELFRA 131_ SGNLV 136_ ITREI 141_ DVAKN 146_ QSFWF 151_ INKKS 156_ TTQKI 161_ VEEKV 166_ AALNI 171_ QVGNL 176_ CQFLP 181_ QDKVG 186_ EFAKL 191_ SKIEL 196_ LEATE 201_ KSIGP 206_ PEMHK 211_ YHCEL 216_ KNLRE 221_ KEKQL 226_ ETSCK 231_ EKTEY 236_ LQKMV 241_ QRNER 246_ YKQDV 251_ ERFYE 256_ RKRHL 261_ DLIEM 266_ LEAKR 271_ PWVEY 276_ ENVRQ 281_ EYEEV 286_ KLVRD 291_ RVKEE 296_ VRKLK 301_ EGQIP 306_ VTCRI 311_ EEMEN 316_ ERHNL 321_ EARIK 326_ EKATD 331_ IKEAS 336_ QKCKQ 341_ KQDVI 346_ ERKDK 351_ HIEEL 356_ QQALI 361_ VKQNE 366_ ELDRQ 371_ RRIGN 376_ TRKMI 381_ EDLQN 386_ ELKTT 391_ ENCEN 396_ LQPQI 401_ DAITN 406_ DLRRI 411_ QDEKA 416_ LCEGE 421_ IIDKR 426_ RERET 431_ LEKEK 436_ KSVDD 441_ HIVRF 446_ DNLMN 451_ QKEDK 456_ LRQRF 461_ RDTYD 466_ AVLWL 471_ RNNRD 476_ KFKQR 481_ VCEPI 486_ MLTIN 491_ MKDNK 496_ NAKYI 501_ ENHIP 506_ SNDLR 511_ AFVFE 516_ SQEDM 521_ EVFLK 526_ EVRDN 531_ KKLRV 536_ NAVIA 541_ PKSSY 546_ ADKAP 551_ SRSLN 556_ ELKQY 561_ GFFSY 566_ LRELF 571_ DAPDP 576_ VMSYL 581_ CCQYH 586_ IHEVP 591_ VGTEK 596_ TRERI 601_ ERVIQ 606_ ETRLK 611_ QIYTA 616_ EEKYV 621_ VKTSF 626_ YSNKV 631_ ISSNT 636_ SLKVA 641_ QFLTV 646_ TVDLE 651_ QRRHL 656_ EEQLK 661_ EIHRK 666_ LQAVD 671_ SGLIA 676_ LRETS 681_ KHLEH 686_ KDNEL 691_ RQKKK 696_ ELLER 701_ KTKKR 706_ QLEQK 711_ ISSKL 716_ GSLKL 721_ MEQDT 726_ CNLEE 731_ EERKA 736_ STKIK 741_ EINVQ 746_ KAKLV 751_ TELTN 756_ LIKIC 761_ TSLHI 766_ QKVDL 771_ ILQNT 776_ TVISE 781_ KNKLE 786_ SDYMA 791_ ASSQL 796_ RLTEQ 801_ HFIEL 806_ DENRQ 811_ RLLQK 816_ CKELM 821_ KRARQ 826_ VCNLG 831_ AEQTL 836_ PQEYQ 841_ TQVPT 846_ IPNGH 851_ NSSLP 856_ MVFQD 861_ LPNTL 866_ DEIDA 871_ LLTEE 876_ RSRAS 881_ CFTGL 886_ NPTIV 891_ QEYTK 896_ REEEI 901_ EQLTE 906_ ELKGK 911_ KVELD 916_ QYREN 921_ ISQVK 926_ ERWLN 931_ PLKEL 936_ VEKIN 941_ EKFSN 946_ FFSSM 951_ QCAGE 956_ VDLHT 961_ ENEED 966_ YDKYG 971_ IRIRV 976_ KFRSS 981_ TQLHE 986_ LTPHH 991_ QSGGE 996_ RSVST 1001_ MLYLM 1006_ ALQEL 1011_ NRCPF 1016_ RVVDE 1021_ INQGM 1026_ DPINE 1031_ RRVFE 1036_ MVVNT 1041_ ACKEN 1046_ TSQYF 1051_ FITPK 1056_ LLQNL 1061_ PYSEK 1066_ MTVLF 1071_ VYNGP 1076_ HMLEP 1081_ NTWNL 1086_ KAFQR 1091_ RRRRI 1096_TFTQP
1: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541)