Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase)
1_MPSPR 6_ RSMEG 11_ RPLGV 16_ SASSS 21_ SSSPG 26_ SPAHG 31_ GGGGG 36_ SRFEF 41_ QSLLS 46_ SRATA 51_ VDPTC 56_ ARLRA 61_ SESPV 66_ HRRGS 71_ FPLAA 76_ AGPSQ 81_ SPAPP 86_ LPEED 91_ RMDLN 96_ PSFLG 101_ IALRS 106_ LLAID 111_ LWLSK 116_ KLGVC 121_ AGESS 126_ SWGSV 131_ RPLMK 136_ LLEIS 141_ GHGIP 146_ WLLGT 151_ LYCLC 156_ RSDSW 161_ AGREV 166_ LMNLL 171_ FALLL 176_ DLLLV 181_ ALIKG 186_ LVRRR 191_ RPAHN 196_ QMDMF 201_ VTLSV 206_ DKYSF 211_ PSGHA 216_ TRAAL 221_ MSRFI 226_ LNHLV 231_ LAIPL 236_ RVLVV 241_ LWAFV 246_ LGLSR 251_ VMLGR 256_ HNVTD 261_ VAFGF 266_ FLGYM 271_ QYSIV 276_ DYCWL 281_ SPHNA 286_PVLFL
1: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354)