Intraflagellar transport protein 20 homolog (hIFT20)
1_MAKDI 6_ LGEAG 11_ LHFDE 16_ LNKLR 21_ VLDPE 26_ VTQQT 31_ IELKE 36_ ECKDF 41_ VDKIG 46_ QFQKI 51_ VGGLI 56_ ELVDQ 61_ LAKEA 66_ ENEKM 71_ KAIGA 76_ RNLLK 81_ SIAKQ 86_ REAQQ 91_ QQLQA 96_ LIAEK 101_ KMQLE 106_ RYRVE 111_ YEALC 116_ KVEAE 121_ QNEFI 126_DQFIF
1: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly (PubMed:17604723). May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity)