Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1)
1_MSTQD 6_ ERQIN 11_ TEYAV 16_ SLLEQ 21_ LKLFY 26_ EQQLF 31_ TDIVL 36_ IVEGT 41_ EFPCH 46_ KMVLA 51_ TCSSY 56_ FRAMF 61_ MSGLS 66_ ESKQT 71_ HVHLR 76_ NVDAA 81_ TLQII 86_ ITYAY 91_ TGNLA 96_ MNDST 101_ VEQLY 106_ ETACF 111_ LQVED 116_ VLQRC 121_ REYLI 126_ KKINA 131_ ENCVR 136_ LLSFA 141_ DLFSC 146_ EELKQ 151_ SAKRM 156_ VEHKF 161_ TAVYH 166_ QDAFM 171_ QLSHD 176_ LLIDI 181_ LSSDN 186_ LNVEK 191_ EETVR 196_ EAAML 201_ WLEYN 206_ TESRS 211_ QYLSS 216_ VLSQI 221_ RIDAL 226_ SEVTQ 231_ RAWFQ 236_ GLPPN 241_ DKSVV 246_ VQGLY 251_ KSMPK 256_ FFKPR 261_ LGMTK 266_ EEMMI 271_ FIEAS 276_ SENPC 281_ SLYSS 286_ VCYSP 291_ QAEKV 296_ YKLCS 301_ PPADL 306_ HKVGT 311_ VVTPD 316_ NDIYI 321_ AGGQV 326_ PLKNT 331_ KTNHS 336_ KTSKL 341_ QTAFR 346_ TVNCF 351_ YWFDA 356_ QQNTW 361_ FPKTP 366_ MLFVR 371_ IKPSL 376_ VCCEG 381_ YIYAI 386_ GGDSV 391_ GGELN 396_ RRTVE 401_ RYDTE 406_ KDEWT 411_ MVSPL 416_ PCAWQ 421_ WSAAV 426_ VVHDC 431_ IYVMT 436_ LNLMY 441_ CYFPR 446_ SDSWV 451_ EMAMR 456_ QTSRS 461_ FASAA 466_ AFGDK 471_ IFYIG 476_ GLHIA 481_ TNSGI 486_ RLPSG 491_ TVDGS 496_ SVTVE 501_ IYDVN 506_ KNEWK 511_ MAANI 516_ PAKRY 521_ SDPCV 526_ RAVVI 531_ SNSLC 536_ VFMRE 541_ THLNE 546_ RAKYV 551_ TYQYD 556_ LELDR 561_ WSLRQ 566_ HISER 571_ VLWDL 576_ GRDFR 581_ CTVGK 586_ LYPSC 591_ LEESP 596_ WKPPT 601_ YLFST 606_ DGTEE 611_ FELDG 616_EMVAL
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation