YY1-associated factor 2
1_MGDKK 6_ SPTRP 11_ KRQPK 16_ PSSDE 21_ GYWDC 26_ SVCTF 31_ RNSAE 36_ AFKCM 41_ MCDVR 46_ KGTST 51_ RKPRP 56_ VSQLV 61_ AQQVT 66_ QQFVP 71_ PTQSK 76_ KEKKD 81_ KVEKE 86_ KSEKE 91_ TTSKK 96_ NSHKK 101_ TRPRL 106_ KNVDR 111_ SSAQH 116_ LEVTV 121_ GDLTV 126_ IITDF 131_ KEKTK 136_ SPPAS 141_ SAASA 146_ DQHSQ 151_ SGSSS 156_ DNTER 161_ GMSRS 166_ SSPRG 171_EASSL
1: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling