pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)
1_MGKKG 6_ KVGKS 11_ RRDKF 16_ YHLAK 21_ ETGYR 26_ SRSAF 31_ KLIQL 36_ NRRFQ 41_ FLQKA 46_ RALLD 51_ LCAAP 56_ GGWLQ 61_ VAAKF 66_ MPVSS 71_ LIVGV 76_ DLVPI 81_ KPLPN 86_ VVTLQ 91_ QDITT 96_ ERCRQ 101_ ALRKE 106_ LKTWK 111_ VDVVL 116_ NDGAP 121_ NVGAS 126_ WVHDA 131_ YSQAH 136_ LTLMA 141_ LRLAC 146_ DFLAR 151_ GGSFI 156_ TKVFR 161_ SRDYQ 166_ PLLWI 171_ FQQLF 176_ RRVQA 181_ TKPQA 186_ SRHES 191_ AEIFV 196_ VCQGF 201_ LAPDK 206_ VDSKF 211_ FDPKF 216_ AFKEV 221_ EVQAK 226_ TVTEL 231_ VTKKK 236_ PKAEG 241_ YAEGD 246_ LTLYH 251_ RTSVT 256_ DFLRA 261_ ANPVD 266_ FLSKA 271_ SEIMV 276_ DDEEL 281_ AQHPA 286_ TTEDI 291_ RVCCQ 296_ DIRVL 301_ GRKEL 306_ RSLLN 311_ WRTKL 316_ RRYVA 321_ KKLKE 326_ QAKAL 331_ DISLS 336_ SGEED 341_ EGDEE 346_ DSTAG 351_ TTKQP 356_ SKEEE 361_ EEEEE 366_ EQLNQ 371_ TLAEM 376_ KAQEV 381_ AELKR 386_ KKKKL 391_ LREQR 396_ KQRER 401_ VELKM 406_ DLPGV 411_ SIADE 416_ GETGM 421_ FSLST 426_ IRGHQ 431_ LLEEV 436_ TQGDM 441_ SAADT 446_ FLSDL 451_ PRDDI 456_ YVSDV 461_ EDDGD 466_ DTSLD 471_ SDLDP 476_ EELAG 481_ VRGHQ 486_ GLRDQ 491_ KRMRL 496_ TEVQD 501_ DKEEE 506_ EEENP 511_ LLVPL 516_ EEKAV 521_ LQEEQ 526_ ANLWF 531_ SKGSF 536_ AGIED 541_ DADEA 546_ LEISQ 551_ AQLLF 556_ ENRRK 561_ GRQQQ 566_ QKQQL 571_ PQTPP 576_ SCLKT 581_ EIMSP 586_ LYQDE 591_ APKGT 596_ EASSG 601_ TEAAT 606_ GLEGE 611_ EKDGI 616_ SDSDS 621_ STSSE 626_ EEESW 631_ EPLRG 636_ KKRSR 641_ GPKSD 646_ DDGFE 651_ IVPIE 656_ DPAKH 661_ RILDP 666_ EGLAL 671_ GAVIA 676_ SSKKA 681_ KRDLI 686_ DNSFN 691_ RYTFN 696_ EDEGE 701_ LPEWF 706_ VQEEK 711_ QHRIR 716_ QLPVG 721_ KKEVE 726_ HYRKR 731_ WREIN 736_ ARPIK 741_ KVAEA 746_ KARKK 751_ RRMLK 756_ RLEQT 761_ RKKAE 766_ AVVNT 771_ VDISE 776_ REKVA 781_ QLRSL 786_ YKKAG 791_ LGKEK 796_ RHVTY 801_ VVAKK 806_ GVGRK 811_ VRRPA 816_ GVRGH 821_ FKVVD 826_ SRMKK 831_ DQRAQ 836_ QRKEQ 841_KKKHK
1: RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation
2: (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973)