Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
1_MKLSV 6_ NEAQL 11_ GFYLG 16_ SLSHL 21_ SACPG 26_ IDPRS 31_ SEDQP 36_ ESLKT 41_ GQMMD 46_ ESDED 51_ FKELC 56_ ASFFQ 61_ RVKKH 66_ GIKEV 71_ SGERK 76_ TQKAA 81_ SNGTQ 86_ IRSKL 91_ KRTKQ 96_ TATKT 101_ KTLQG 106_ PAEKK 111_ PPSGS 116_ QAPRT 121_ KKQRV 126_ TKWQA 131_ SEPAH 136_ SVNGE 141_ GGVLA 146_ SAPDP 151_ PVLRE 156_ TAQNT 161_ QTGNQ 166_ QEPSP 171_ NLSRE 176_ KTREN 181_ VPNSD 186_ SQPPP 191_ SCLTT 196_ AVPSP 201_ SKPRT 206_ AQLVL 211_ QRMQQ 216_ FKRAD 221_ PERLR 226_ HASEE 231_ CSLEA 236_ AREEN 241_ VPKDP 246_ QEEMM 251_ AGNVY 256_ GLGPP 261_ APESD 266_ AAVAL 271_ TLQQE 276_ FARVG 281_ ASAHD 286_ DSLEE 291_ KGLFF 296_ CQICQ 301_ KNLSA 306_ MNVTR 311_ REQHV 316_ NRCLD 321_ EAEKT 326_ LRPSV 331_ PQIPE 336_ CPICG 341_ KPFLT 346_ LKSRT 351_ SHLKQ 356_ CAVKM 361_ EVGPQ 366_ LLLQA 371_ VRLQT 376_ AQPEG 381_ SSSPP 386_ MFSFS 391_ DHSRG 396_ LKRRG 401_ PTSKK 406_ EPRKR 411_ RKVDE 416_ APSED 421_ LLVAM 426_ ALSRS 431_ EMEPG 436_ AAVPA 441_ LRLES 446_ AFSER 451_ IRPEA 456_ ENKSR 461_ KKKPP 466_ VSPPL 471_ LLVQD 476_ SETTG 481_ RQIED 486_ RVALL 491_ LSEEV 496_ ELSST 501_ PPLPA 506_ SRILK 511_ EGWER 516_ AGQCP 521_ PPPER 526_ KQSFL 531_ WEGSA 536_ LTGAW 541_ AMEDF 546_ YTARL 551_ VPPLV 556_ PQRPA 561_ QGLMQ 566_ EPVPP 571_ LVPPE 576_ HSELS 581_ ERRSP 586_ ALHGT 591_ PTAGC 596_ GSRGP 601_ SPSAS 606_ QREHQ 611_ ALQDL 616_ VDLAR 621_ EGLSA 626_ SPWPG 631_ SGGLA 636_ GSEGT 641_ AGLDV 646_ VPGGL 651_ PLTGF 656_ VVPSQ 661_ DKHPD 666_ RGGRT 671_ LLSLG 676_ LLVAD 681_ FGAMV 686_ NNPHL 691_ SDVQF 696_ QTDSG 701_ EVLYA 706_ HKFVL 711_ YARCP 716_ LLIQY 721_ VNNEG 726_ FSAVE 731_ DGVLT 736_ QRVLL 741_ GDVST 746_ EAART 751_ FLHYL 756_ YTADT 761_ GLPPG 766_ LSSEL 771_ SSLAH 776_ RFGVS 781_ ELVHL 786_ CEQVP 791_ IATDS 796_ EGKPW 801_ EEKEA 806_ ENCES 811_ RAENF 816_ QELLR 821_ SMWAD 826_ EEEEA 831_ ETLLK 836_ SKDHE 841_ EDQEN 846_ VNEAE 851_ MEEIY 856_ EFAAT 861_ QRKLL 866_ QEERA 871_ AGAGE 876_ DADWL 881_ EGGSP 886_ VSGQL 891_ LAGVQ 896_ VQKQW 901_ DKVEE 906_ MEPLE 911_ PGRDE 916_ AATTW 921_ EKMGQ 926_ CALPP 931_ PQGQH 936_ SGARG 941_ AEAPE 946_ QEAPE 951_ EALGH 956_ SSCSS 961_ PSRDC 966_ QAERK 971_ EGSLP 976_ HSDDA 981_ GDYEQ 986_ LFSST 991_ QGEIS 996_ EPSQI 1001_ TSEPE 1006_ EQSGA 1011_ VRERG 1016_ LEVSH 1021_ RLAPW 1026_ QASPP 1031_ HPCRF 1036_ LLGPP 1041_ QGGSP 1046_ RGSHH 1051_ TSGSS 1056_ LSTPR 1061_ SRGGT 1066_ SQVGS 1071_ PTLLS 1076_ PAVPS 1081_ KQKRD 1086_ RSILT 1091_ LSKEP 1096_ GHQKG 1101_ KERRS 1106_ VLECR 1111_ NKGVL 1116_ MFPEK 1121_ SPSID 1126_ LTQSN 1131_ PDHSS 1136_ SRSQK 1141_ SSSKL 1146_ NEEDE 1151_ VILLL 1156_ DSDEE 1161_ LELEQ 1166_ TKMKS 1171_ ISSDP 1176_ LEEKK 1181_ ALEIS 1186_ PRSCE 1191_ LFSII 1196_ DVDAD 1201_ QEPSQ 1206_ SPPRS 1211_ EAVLQ 1216_ QEDEG 1221_ ALPEN 1226_ RGSLG 1231_ RRGAP 1236_ WLFCD 1241_ RESSP 1246_ SEAST 1251_ TDTSW 1256_ LVPAT 1261_ PLASR 1266_ SRDCS 1271_ SQTQI 1276_ SSLRS 1281_ GLAVQ 1286_ AVTQH 1291_ TPRAS 1296_ VGNRE 1301_ GNEVA 1306_ QKFSV 1311_ IRPQT 1316_ PPPQT 1321_ PSSCL 1326_ TPVSP 1331_ GTSDG 1336_ RRQGH 1341_ RSPSR 1346_ PHPGG 1351_ HPHSS 1356_ PLAPH 1361_ PISGD 1366_ RAHFS 1371_ RRFLK 1376_ HSPPG 1381_ PSFLN 1386_ QTPAG 1391_ EVVEV 1396_ GDSDD 1401_ EQEVA 1406_ SHQAN 1411_ RSPPL 1416_ DSDPP 1421_ IPIDD 1426_ CCWHM 1431_ EPLSP 1436_ IPIDH 1441_ WNLER 1446_ TGPLS 1451_ TSSPS 1456_ RRMNE 1461_ AADSR 1466_ DCRSP 1471_ GLLDT 1476_ TPIRG 1481_ SCTTQ 1486_ RKLQE 1491_ KSSGA 1496_ GSLGN 1501_ SRPSF 1506_ LNSAL 1511_ WDVWD 1516_ GEEQR 1521_ PPETP 1526_ PPAQM 1531_ PSAGG 1536_ AQKPE 1541_ GLETP 1546_ KGANR 1551_ KKNLP 1556_ PKVPI 1561_ TPMPQ 1566_ YSIME 1571_ TPVLK 1576_ KELDR 1581_ FGVRP 1586_ LPKRQ 1591_ MVLKL 1596_ KEIFQ 1601_ YTHQT 1606_ LDSDS 1611_ EDESQ 1616_ SSQPL 1621_ LQAPH 1626_ CQTLA 1631_ SQTYK 1636_ PSRAG 1641_ VHAQQ 1646_ EATTG 1651_ PGAHR 1656_ PKGPA 1661_ KTKGP 1666_ RHQRK 1671_ HHESI 1676_ TPPSR 1681_ SPTKE 1686_ APPGL 1691_ NDDAQ 1696_ IPASQ 1701_ ESVAT 1706_ SVDGS 1711_ DSSLS 1716_ SQSSS 1721_ SCEFG 1726_ AAFES 1731_ AGEEE 1736_ GEGEV 1741_ SASQA 1746_ AVQAA 1751_ DTDEA 1756_ LRCYI 1761_ RSKPA 1766_ LYQKV 1771_ LLYQP 1776_ FELRE 1781_ LQAEL 1786_ RQNGL 1791_ RVSSR 1796_ RLLDF 1801_ LDTHC 1806_ ITFTT 1811_ AATRR 1816_ EKLQG 1821_ RRRQP 1826_RGKKK
1: Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks