Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36)
1_MNFNV 6_ WNIKE 11_ MLSIP 16_ SGSGN 21_ KKSSN 26_ WNNNQ 31_ NDYSS 36_ LSDSQ 41_ FLFGS 46_ QFCPE 51_ NSETL 56_ SAPLD 61_ FGAHL 66_ RHSKQ 71_ SQQNY 76_ LEGEP 81_ SIFTK 86_ YQTKP 91_ QLFGG 96_ DIKDG 101_ GLFPP 106_ PLSVG 111_ KSKGL 116_ LEQFE 121_ EKKKR 126_ AKDKC 131_ DSETL 136_ YNFVS 141_ NVRES 146_ ILRLQ 151_ TSVEK 156_ SEDHL 161_ SSRSQ 166_ SILDS 171_ LETVA 176_ KTLQE 181_ TIQAQ 186_ NDLVF 191_ EAVQD 196_ KGNME 201_ QAILE 206_ MKKRF 211_ EARQG 216_ EFIEM 221_ KSNLK 226_ HLEVL 231_ VAQQS 236_ QEFQQ 241_ LCEQL 246_ GQLNV 251_ PSVLA 256_ ELKRL 261_ ISVPP 266_ VKDSA 271_ SQTSP 276_ PLAQS 281_ LNLTR 286_ QEKYT 291_ SEKPV 296_ LWQAQ 301_ ALPAA 306_ WNPGM 311_ GSLQP 316_ GEFDV 321_ WGEGA 326_ KNDDL 331_ QEEAA 336_ LPAFG 341_ SHERN 346_ RHVKD 351_ KVVQT 356_ NCKNW 361_ AVTKT 366_ GAKNH 371_ GSSVP 376_ GHKIP 381_ SDRDL 386_ VSQGA 391_ SQLTS 396_ LEINF 401_ STSIK 406_ NACQK 411_ YQAQS 416_ MFLCD 421_ PREHL 426_ VIKQK 431_ DGTVE 436_ MRGKD 441_ KKQQP 446_ RKAHR 451_ AHRGR 456_ LIASK 461_ QKQIP 466_ IQTCK 471_ FNSKY 476_ QSPQP 481_ AISVP 486_ QSPFL 491_ GQQEP 496_ RAQPL 501_ HLQCP 506_ RSPRK 511_ PVCPI 516_ LGGTV 521_ MPNKT 526_ VRAVQ 531_ GRLLQ 536_ LSRCS 541_ SQDNW 546_ LLSSS 551_ SQGDH 556_ QMSWF 561_ SDLNL 566_ GCSET 571_ PLCKE 576_ AGKNL 581_ LYDLG 586_FDSSD
1: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance