Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)
1_MDAGF 6_ FRGTS 11_ AEQDN 16_ RFSNK 21_ QKKLL 26_ KQLKF 31_ AECLE 36_ KKVDM 41_ SKVNL 46_ EVIKP 51_ WITKR 56_ VTEIL 61_ GFEDD 66_ VVIEF 71_ IFNQL 76_ EVKNP 81_ DSKMM 86_ QINLT 91_ GFLNG 96_ KNARE 101_ FMGEL 106_ WPLLL 111_ SAQEN 116_ IAGIP 121_ SAFLE 126_ LKKEE 131_ IKQRQ 136_ IEQEK 141_ LASMK 146_ KQDED 151_ KDKRD 156_ KEEKE 161_ SSREK 166_ RERSR 171_ SPRRR 176_ KSRSP 181_ SPRRR 186_ SSPVR 191_ RERKR 196_ SHSRS 201_ PRHRT 206_ KSRSP 211_ SPAPE 216_ KKEKT 221_ PELPE 226_ PSVKV 231_ KEPSV 236_ QEATS 241_ TSDIL 246_ KVPKP 251_ EPIPE 256_ PKEPS 261_ PEKNS 266_ KKEKE 271_ KEKTR 276_ PRSRS 281_ RSKSR 286_ SRTRS 291_ RSPSH 296_ TRPRR 301_ RHRSR 306_ SRSYS 311_ PRRRP 316_ SPRRR 321_ PSPRR 326_ RTPPR 331_ RMPPP 336_ PRHRR 341_ SRSPV 346_ RRRRR 351_ SSASL 356_ SGSSS 361_ SSSSS 366_ RSRSP 371_ PKKPP 376_ KRTSS 381_ PPRKT 386_ RRLSP 391_ SASPP 396_ RRRHR 401_ PSPPA 406_ TPPPK 411_ TRHSP 416_ TPQQS 421_ NRTRK 426_ SRVSV 431_ SPGRT 436_ SGKVT 441_ KHKGT 446_ EKRES 451_ PSPAP 456_ KPRKV 461_ ELSES 466_ EEDKG 471_ GKMAA 476_ ADSVQ 481_ QRRQY 486_ RRQNQ 491_ QSSSD 496_ SGSSS 501_ SSEDE 506_ RPKRS 511_ HVKNG 516_ EVGRR 521_ RRHSP 526_ SRSAS 531_ PSPRK 536_ RQKET 541_ SPRGR 546_ RRRSP 551_ SPPPT 556_ RRRRS 561_ PSPAP 566_ PPRRR 571_ RTPTP 576_ PPRRR 581_ TPSPP 586_ PRRRS 591_ PSPRR 596_ YSPPI 601_ QRRYS 606_ PSPPP 611_ KRRTA 616_ SPPPP 621_ PKRRA 626_ SPSPP 631_ PKRRV 636_ SHSPP 641_ PKQRS 646_ SPVTK 651_ RRSPS 656_ LSSKH 661_ RKGSS 666_ PSRST 671_ REARS 676_ PQPNK 681_ RHSPS 686_ PRPRA 691_ PQTSS 696_ SPPPV 701_ RRGAS 706_ SSPQR 711_ RQSPS 716_ PSTRP 721_ IRRVS 726_ RTPEP 731_ KKIKK 736_ AASPS 741_ PQSVR 746_ RVSSS 751_ RSVSG 756_ SPEPA 761_ AKKPP 766_ APPSP 771_ VQSQS 776_ PSTNW 781_ SPAVP 786_ VKKAK 791_ SPTPS 796_ PSPPR 801_ NSDQE 806_ GGGKK 811_ KKKKK 816_ DKKHK 821_ KDKKH 826_ KKHKK 831_ HKKEK 836_ AVAAA 841_ AAAAV 846_ TPAAI 851_ AAATT 856_ TLAQE 861_ EPVAA 866_ PEPKK 871_ ETESE 876_ AEDNL 881_ DDLEK 886_ HLREK 891_ ALRSM 896_RKAQV
1: Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates